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Moumoujus

CYCLO PEG-6.

Valuable CAS 17455-13-9 / NOT REPORTED

CYCLO PEG-6 is a synthetic polymer derived from polyethylene glycol, primarily utilized in skincare formulations for its multifaceted functional properties. It acts as a humectant, drawing moisture into the skin, and serves as an emulsifier to blend oil and water components, alongside its role as a solvent and carrier for active ingredients.

Summary

Humectant Emulsifier Solvent Carrier

Science

Mechanism of Action

While specific mechanisms of action for CYCLO PEG-6 on the skin are not explicitly detailed, it aligns with the known functions of polyethylene glycols. It primarily operates as a humectant, attracting and retaining water molecules to enhance skin hydration. Additionally, it functions as an emulsifier, stabilizing oil-in-water or water-in-oil formulations, and serves as a solvent or vehicle, facilitating the dispersion and delivery of other active ingredients within a product.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No information regarding dusting potential for CYCLO PEG-6 was found in the available research data.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Polyethylene glycols, including CYCLO PEG-6, are highly water-soluble. Their stability in solution can be compromised by environmental factors such as elevated temperatures, light exposure, and the presence of oxygen, which accelerate degradation. Optimal stability is achieved when solutions are stored frozen, with refrigerated solutions showing improved stability over those at room temperature. Minimizing oxygen exposure through inert gas purging (e.g., argon) and light protection is recommended to further enhance shelf-life.

Conflicts

  • PEG-6 may form complexes with certain active substances, potentially leading to their inactivation, as observed with compounds like Penicillin G and Bacitracine. The impact of PEGs on the efficacy and bioavailability of other active ingredients requires individual evaluation during formulation development.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

Although CYCLO PEG-6 specifically lacks a dedicated Cosmetic Ingredient Review (CIR) assessment, the broader class of Polyethylene Glycols (PEGs), including PEG-6, has been rigorously evaluated by the CIR Expert Panel and deemed safe for use in cosmetics. PEGs are also recognized as FDA-approved polymers with established safety profiles. They are generally considered non-comedogenic and exhibit minimal acute toxicity, demonstrating good compatibility with most skin types. However, a small subset of individuals, particularly those with highly sensitive skin, may experience irritation or allergic reactions. Formulators should also be aware of historical concerns regarding potential impurities, such as 1,4-dioxane, in some PEG compounds, though reputable manufacturers typically employ processes to mitigate these risks.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Low

Our Assessment

Verdict

Valuable

CYCLO PEG-6 is a valuable polyfunctional ingredient, offering humectant, emulsifying, and solvent properties with a generally favorable safety profile, though specific clinical efficacy data for this derivative is currently limited.

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