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Moumoujus

CUTIBACTERIUM AVIDUM/GRANULOSUM FERMENT EXTRACT FILTRATE.

Valuable / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

This ingredient is a fermented extract filtrate derived from Cutibacterium avidum and granulosum, beneficial bacteria known for their role in skin health. It is precisely engineered to offer a multifaceted approach to skin conditioning, addressing concerns from barrier integrity to inflammatory responses.

Summary

Skin Conditioning Emollient Anti-inflammatory Antimicrobial Barrier Support Moisturizing

Science

Mechanism of Action

Functioning as a sophisticated skin conditioning agent and emollient, this ingredient actively softens and smooths the skin. Its fermented components are shown to enhance the skin barrier by facilitating the expression of vital proteins like filaggrin and claudin 1. It exerts anti-inflammatory actions by reducing the expression of specific cytokines, including TSLP, IL-8, and IL-6. Furthermore, it exhibits antimicrobial activity through the inhibition of Staphylococcus aureus growth and biofilm formation, contributing to improved skin moisturization and overall dermal health.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A patent study (US20210299189A1) demonstrated that fermented filtrates of Cutibacterium avidum GENSC01 strain were effective in improving, preventing, or treating atopic dermatitis, acne, and various inflammatory skin diseases, including those exacerbated by fine dust. This efficacy was linked to facilitated filaggrin and claudin 1 expression, coupled with a reduction in inflammatory cytokines such as TSLP, IL-8, and IL-6.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

While direct stability data for the extract is not explicitly stated, studies on related Cutibacterium avidum and granulosum suggest optimal enzyme activity, such as lipase production, around pH 5.5. Enzyme denaturation may occur outside the optimal pH range of 4.5-6.5, which closely matches the skin's natural acidic pH.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No direct safety assessments by CIR, SCCS, or FDA for this specific ingredient were identified. However, a particular strain of Cutibacterium avidum (GENSC01) has shown no hemolytic toxicity, suggesting it is not harmful. INCI Beauty reports 'No penalty' across all categories for this ingredient, and 'Cutibacterium Granulosum Ferment Extract Filtrate' is listed as 'Irritant Free' by SkinSAFE, indicating a favorable safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

This fermented extract is a valuable ingredient for comprehensive skin health, offering significant benefits in barrier fortification, anti-inflammatory action, and antimicrobial defense across all skin types with a low risk of irritation or comedogenicity.

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