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Moumoujus

CURCUMA ZEDOARIA ROOT EXTRACT.

Valuable CAS 84961-49-9 / SKIN CONDITIONING

Curcuma Zedoaria Root Extract is a botanical active renowned for its multifunctional benefits in skincare. Rich in curcuminoids, it offers potent anti-inflammatory, antioxidant, and antimicrobial properties. This extract is designed to soothe irritated skin, combat breakouts, and promote a more even and radiant complexion.

Summary

Skin Conditioning Anti-inflammatory Antioxidant Antimicrobial Sebum regulating Skin regenerating Brightening Soothing

Science

Mechanism of Action

This extract leverages its diverse phytochemical profile, including curcumin, to exert broad-spectrum benefits. It functions as a powerful anti-inflammatory, mitigating redness and swelling, which is beneficial for compromised skin conditions. As a robust antioxidant, it neutralizes free radicals, thereby protecting cellular integrity and contributing to anti-aging effects by potentially supporting collagen and elastin synthesis. Its antimicrobial, antibacterial, and antifungal actions help to manage skin infections and reduce breakout frequency. Furthermore, the extract assists in sebum regulation, aids in skin regeneration and cell renewal, and contributes to skin brightening by reducing hyperpigmentation and evening out tone, while providing a general soothing effect.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An ethanolic extract of steamed rhizomes demonstrated significant anti-inflammatory activity in vitro, exhibiting an IC50 of 11.22 ± 1.21 µg/mL by inhibiting nitric oxide production.
  2. 02 Multiple in vitro assays confirmed potent antioxidant activity. A methanolic extract achieved 90.102% inhibition of free radicals at 500 µg/ml, while specific fractions showed IC50 values of 153.49 ± 2.66 ppm and 185.77 ± 3.91 ppm in DPPH assays.
  3. 03 In vitro studies indicated effective inhibition of common skin pathogens including Streptococcus mutants, Enterococcus faecalis, Staphylococcus aureus, and Candida albicans.
  4. 04 In Wistar rats, 5%, 10%, and 20% concentrations, when used as endodontic irrigation, significantly reduced the expression of the pro-inflammatory cytokine TNF-α.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data to determine dusting prevalence or thresholds for topical formulations.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 6
0 7 14

Stability

The key constituent, curcumin, exhibits optimal solubility and absorbance within a pH range of 4.0 to 6.0. Formulations, such as anti-inflammatory creams, have demonstrated stability when incorporating aqueous Curcuma Zedoaria Root Extract at a pH of 6.0.

Conflicts

  • Ascorbic acid (specific to curcumin component)
  • Ethyl cellulose (EC) (specific to curcumin component)
  • Sodium carboxymethylcellulose (Na-CMC) (specific to curcumin component)
  • Magnesium stearate (specific to curcumin component)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Curcuma Zedoaria Root Extract has not been specifically reviewed by the Cosmetic Ingredient Review (CIR) Panel. A related species, Curcuma Longa (Turmeric) Root Extract, is slated for CIR review in 2024. While curcumin, a component, was delisted as a food colorant by the FDA, Curcuma Zedoaria is generally considered safe for traditional medicinal uses with minimal reported side effects.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Curcuma Zedoaria Root Extract is a valuable ingredient, demonstrating robust in vitro anti-inflammatory, antioxidant, and antimicrobial activities, making it highly beneficial for diverse skin concerns.

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