Science
Mechanism of Action
This extract operates by regulating the NHE1 protein, a key component in the skin's intrinsic pH control system. Proper pH is essential for lipid-processing enzymes, which in turn fortify the skin barrier, leading to reduced sensitivity. Additionally, its richness in sugars and phenolic glycosides bestows significant antioxidant, anti-inflammatory, and radical scavenging benefits.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A clinical study indicated that concentrations between 3% and 5% effectively decrease skin reactivity and sensitivity. This is achieved through the regulation of the NHE1 protein, which supports the skin's internal pH balance and thus repairs the barrier function.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For optimal preservation, store in a dry environment.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not yet reviewed Curculigo Orchioides Root Extract, and specific cosmetic safety assessments by bodies such as SCCS or FDA are not readily available. Acute oral toxicity studies in mice with the root extract demonstrated no adverse effects or mortality at a dose of 2000 mg/kg. It is crucial to note that preliminary studies on the aqueous *leaf* extract of C. orchioides indicated organismal toxicity in Drosophila melanogaster, which should not be conflated with the safety profile of the *root* extract utilized in cosmetics.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This root extract is a valuable ingredient for calming sensitive skin and fortifying the skin barrier through its pH-regulating and protective antioxidant properties.
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