Science
Mechanism of Action
This extract operates through multiple pathways to enhance dermal health. It significantly modulates inflammatory responses by inhibiting key pro-inflammatory cytokines, specifically IL-6 and IL-8, and reducing chemokines such as RANTES and TARC. Furthermore, it downregulates ICAM-1 and impedes the nuclear translocation of NF-κB p65, preventing IκBα degradation. As a potent antioxidant, it fortifies the skin's defense systems by activating the Nrf2/HO-1 pathway, boosting endogenous antioxidant enzyme activities, mitigating lipid peroxidation, and scavenging reactive oxygen species (ROS). Additionally, it promotes skin brightening by inhibiting tyrosinase and demonstrates anti-aging capabilities through elastase inhibition.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A 0.05% concentration of *Cudrania tricuspidata root extract* demonstrated significant skin brightening and anti-aging effects, inhibiting tyrosinase activity by 81% and elastase activity by 58%.
- 02 Topical application of *Cudrania tricuspidata stem extract* in a mouse model of atopic dermatitis-like skin lesions showed dose-dependent anti-inflammatory efficacy. Concentrations of 0.75%, 2.5%, and 7.5% reduced lesions by 63.6%, 66.1%, and 49.6% respectively after 14 days, with the 2.5% concentration achieving the highest reduction in this study. Serum IgE production was also significantly reduced across these concentrations.
Transparency
Dusting Analysis
No specific data regarding dusting practices or typical formulation percentages for Cudrania Tricuspidata Bark Extract is available in the provided research. Clinical studies on other parts of the plant, demonstrating efficacy, utilize concentrations ranging from 0.05% to 7.5%.
The Formula
Formulation
Stability
Formulations containing Cudrania tricuspidata root extract exhibited stability at 25 °C over 21 days. However, at elevated temperatures (47 °C), significant deviations in viscosity and particle size were observed, indicating potential temperature sensitivity for certain components or overall formulation stability. Specific active components that inhibit H2R are noted to be hydrophobic, suggesting better extraction and compatibility with oil or ethanol bases, while other beneficial constituents are water-extractable, allowing for versatile formulation approaches.
Safety
Safety Profile
Cudrania Tricuspidata Bark Extract has not been reviewed by the Cosmetic Ingredient Review (CIR) panel. Specific GHS classifications for hazards or dermal toxicity data directly pertaining to the bark extract are not available. Research on other parts of the Cudrania tricuspidata plant (root, branch, fruit) indicated no cell toxicity up to 1000 µg/mL. In contrast, leaf extract demonstrated significant cell toxicity at concentrations exceeding 200 µg/mL, highlighting potential differences in safety profiles among various plant components. Further dedicated safety assessments for the bark extract are recommended.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cudrania Tricuspidata Bark Extract is a valuable ingredient, demonstrating significant anti-inflammatory, antioxidant, brightening, and anti-aging properties, making it suitable for a wide range of skin concerns despite limited direct clinical studies on the bark itself at specific concentrations.
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References
Sources