Science
Mechanism of Action
The extract's efficacy is attributed to its high concentration of bioactive compounds, such as beta-carotene, lutein, zeaxanthin, flavonoids, phenols, and vitamins B, C, and E. These components collectively provide potent antioxidant action by neutralizing reactive oxygen species, thereby mitigating oxidative stress. Additionally, it acts as a humectant, drawing and retaining moisture in the skin, and contributes to overall skin protection. Studies also note its anti-inflammatory, anti-aging, and soothing properties.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 Clinical evaluation of Cucurbita moschata polysaccharide extract at concentrations of 0.05% to 0.1% demonstrated a significant increase in skin moisturizing ability in human volunteers, with no reported skin irritation.
- 02 In vitro assessments of Cucurbita spp. peel extracts showed they were non-cytotoxic to human keratinocytes and considered non-irritant for the skin at concentrations up to 1000 µg/mL (0.1%).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This extract is typically prepared in water and glycerin. Its optimal stability range is between pH 4.0 and 6.5, a range generally consistent with extracts from related Cucurbita species.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not formally reviewed Cucurbita Maxima Fruit Extract, citing insufficient data. However, in vitro studies on related Cucurbita spp. peel extracts indicate non-cytotoxicity to human keratinocytes and non-irritancy to the skin at concentrations up to 0.1% (1000 µg/mL).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cucurbita Maxima Fruit Extract is a valuable ingredient, offering antioxidant, hydrating, and soothing benefits with a low risk of irritation, making it suitable for a wide range of skin types.
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