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Moumoujus

CRYPTOMERIA JAPONICA BARK.

Valuable CAS 91771-60-7 / SKIN CONDITIONING

Derived from the Japanese Cedar, Cryptomeria Japonica Bark is a potent botanical extract with a diverse array of benefits for precision skincare. It acts as an effective skin conditioning agent, while delivering significant antibacterial, antioxidant, and melanin-inhibiting properties.

Summary

Antibacterial Antioxidant Brightening Antifungal Skin Conditioning

Science

Mechanism of Action

Cryptomeria Japonica Bark's efficacy is largely attributed to its rich content of diterpenoids, including ferruginol and isopimaric acid, which exert antibacterial effects by disrupting bacterial growth. The extract also possesses robust antioxidant capabilities, evidenced by DPPH radical scavenging, ORAC, and SOD-like activities, which collectively protect skin cells from oxidative stress. Additionally, it actively inhibits melanin biosynthesis, contributing to a brighter complexion, and exhibits antifungal properties.

Research

Clinical Evidence

Medium confidence
Effective range 25–250%
Optimal

N/A

Key findings

  1. 01 An ethanolic extract demonstrated good antibacterial activity against various bacteria at 250 µg/mL.
  2. 02 Ferruginol, isolated from the bark, exhibited strong antibacterial activity against all tested bacteria within a range of 6.3 to 12.5 µg/mL.
  3. 03 Isopimaric acid, another compound from the bark, showed good antibacterial activity against Staphylococcus aureus at 6.25 µg/mL.
  4. 04 Ethyl acetate exudates of the bark displayed strong antibacterial effects against both Gram-negative (Escherichia coli) and Gram-positive bacteria (including Staphylococcus aureus, MRSA, S. epidermidis, Enterococcus faecalis) at concentrations between 25-250 µg/mL.
  5. 05 Bark exudates exhibited 79% antioxidant activity, with ferruginol contributing 53%, measured via DPPH radical scavenging at 100 µg/mL.
  6. 06 Methanol extracts demonstrated strong antioxidant activity (ORAC of 7.64 mg±0.18 TE/mg and high SOD-like activity) and inhibited melanin biosynthesis.
  7. 07 Abietane diterpenoids from the bark (compounds 5 and 6) showed antifungal activities against wood decay fungi, with inhibitions of 37.2% and 46.7% respectively at 100 µg/mL.

Transparency

Dusting Analysis

Not commonly dusted

No specific data is available regarding common dusting or dusting thresholds for Cryptomeria Japonica Bark.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Optimal pH and specific stability considerations for this ingredient are not detailed in the available research.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

No GHS classification, hazard statements, or standard toxicity data (oral, dermal, inhalation) were identified. While recommended as a skin conditioning agent, related extracts suggest adhering to specified concentrations and performing skin patch tests, particularly for sensitive skin types, due to a potential for irritation, especially when formulated with other problematic ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Cryptomeria Japonica Bark is a valuable multi-functional ingredient for precision skincare, offering significant antibacterial, antioxidant, and brightening benefits across all skin types, with careful consideration for sensitive skin during formulation.

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