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Moumoujus

CROTON LECHLERI SAP EXTRACT.

Valuable / SKIN CONDITIONING

Croton Lechleri Sap Extract, commonly known as Dragon's Blood, is a potent botanical renowned for its exceptional capacity to support skin regeneration and bolster barrier function. It effectively forms a protective 'second skin' while delivering significant anti-inflammatory and antioxidant benefits to the complexion.

Summary

Skin Conditioning Antioxidant Anti-inflammatory Wound Healing Moisturizing Astringent Barrier Reinforcement Collagen Stimulation Redness Reduction

Science

Mechanism of Action

This extract functions by forming a biomimetic, protective film on the skin's surface, effectively acting as a 'second skin' to support natural healing processes and defend against environmental stressors. Internally, it potently scavenges free radicals, mitigating oxidative stress, and significantly reduces inflammation. It stimulates crucial cellular activities such as fibroblast proliferation and migration, enhancing the synthesis of type 1 procollagen, which is vital for epidermal repair and elasticity. Furthermore, it helps regulate melanin release, provides moisturizing benefits, and diminishes UV-induced MMP-1 biosynthesis, contributing to its anti-aging profile. Its inherent antimicrobial and vasoconstrictive properties further support its role in soothing sensitive and compromised skin, including conditions like rosacea.

Research

Clinical Evidence

High confidence
Effective range 15%–20%%
Optimal

20%

Key findings

  1. 01 A randomized, double-blind, placebo-controlled clinical trial demonstrated significant wound healing effects when a 15% ethanolic extract of Croton lechleri was incorporated into a cream.
  2. 02 For soothing sensitive skin and reducing redness, a 20% concentration proved most effective in a clinical context.
  3. 03 In vitro studies at this concentration indicated the extract's capacity to inhibit BSA glycation and protect against LDL oxidation, demonstrating anti-glycation and antioxidant potential.
  4. 04 Further in vitro research observed a significant reduction in both baseline and hydrogen peroxide-induced Reactive Oxygen Species (ROS) production in HUVEC cells, confirming its antioxidant prowess.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The deep reddish-brown color of the extract may impart a hue to final formulations. Studies suggest higher polyphenol stability at ambient temperatures (21°C) compared to colder conditions (4°C) for sap samples.

Conflicts

  • Individuals with known latex allergies should avoid this ingredient due to potential cross-reactivity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Croton Lechleri Sap Extract is generally considered safe and effective, particularly in sensitive and problem skin products, with clinical trials supporting its role as a healing agent. However, while topical cosmetic formulations are less concentrated, patch testing is advised prior to full integration, as irritant contact dermatitis has been reported with pure dragon's blood powder or resin. The FDA UNII for Croton Lechleri Resin Extract is GGG6W25C63.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Croton Lechleri Sap Extract is a valuable, multifaceted ingredient celebrated for its ability to foster skin regeneration, reduce inflammation and oxidative stress, and enhance barrier function across all skin types.

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