Science
Mechanism of Action
As a cross-linked cellulose derivative, Croscarmellose rapidly absorbs and swells significantly upon contact with water, creating viscosity within formulations. This action effectively stabilizes emulsions and suspensions, preserving product integrity and uniformity. Its capacity for moisture retention further aids in hydrating the skin and improving the sensorial experience during product application.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Croscarmellose exhibits stability across a broad pH range. However, it is incompatible with highly alkaline environments where pH values exceed 9.0. Under these basic conditions, its ester cross-links can undergo partial or complete hydrolysis, forming more water-soluble by-products that may lead to an uncontrolled increase in viscosity or gel formation upon moisture uptake. Its cross-linked nature renders it water-insoluble, yet capable of rapid and extensive water absorption.
Conflicts
- alkaline excipients (pH > 9)
Safety
Safety Profile
Approved by the U.S. FDA as a pharmaceutical additive, Croscarmellose is generally regarded as non-toxic and non-irritant for topical applications, demonstrating biocompatibility with the skin. While rare instances of allergic reactions, including anaphylactic shock, have been reported following injection, such risks are considered negligible for cosmetic topical use. This ingredient does not meet GHS hazard criteria.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Croscarmellose is a valuable excipient, primarily enhancing product texture and stability while offering a minor contribution to skin hydration and improved application aesthetics.
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References
Sources