Science
Mechanism of Action
This extract operates by suppressing the expression of the iNOS gene and inhibiting the production of nitric oxide (NO). It further interrupts the inflammatory cascade by blocking the release of key mediators, specifically Prostaglandin E2 (PGE2) and the pro-inflammatory cytokines Interleukin-6 (IL-6) and Interleukin-8 (IL-8), while providing secondary antimicrobial and antioxidant support.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 Demonstrated 50% inhibitory concentration (IC50) for nitric oxide production at 58.5 μg/ml.
- 02 Achieved near-total inhibition of H2O2-induced PGE2 release at a concentration of 0.05% in human fibroblasts.
- 03 Complete suppression of IL-8 release observed at concentrations exceeding 0.0025%.
- 04 Achieved significant inhibition of IL-6 inflammatory response at a 1.0% inclusion rate.
Transparency
Dusting Analysis
While it shows molecular activity at very low levels (0.0025% for IL-8), its primary anti-inflammatory benefits for PGE2 and IL-6 require concentrations between 0.05% and 1.0%. Formulas listing this ingredient at the very bottom of the deck (below 0.01%) are likely using it for marketing claims rather than physiological effect.
The Formula
Formulation
Stability
The extract's key protein constituents remain active across a wide pH range (4.5–11.5), though the stability of the full phytochemical profile is optimized near a pH of 8.5.
Synergies
- Antioxidants
- Soothing agents like Bisabolol
- Wound-healing actives
Safety
Safety Profile
While the raw plant material contains toxic alkaloids if ingested, clinical topical testing on humans confirms the extract does not provoke cumulative irritation or sensitization when applied to the skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance botanical for precision soothing, backed by clear data showing significant cytokine inhibition at relatively low concentrations.
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