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Moumoujus

CRINUM ASIATICUM ROOT EXTRACT.

Valuable CAS 93333-92-7 / SKIN CONDITIONING

Crinum Asiaticum Root Extract is a multi-functional botanical ingredient recognized for its potent anti-inflammatory and antioxidant properties. It actively works to soothe skin, mitigate oxidative stress, and enhance cellular vitality, making it a valuable addition to precision skincare formulations.

Summary

antioxidant skin-conditioning anti-inflammatory antimicrobial cell proliferation support hair growth support

Science

Mechanism of Action

This extract exerts its dermatological benefits through multiple mechanistic pathways. It demonstrates robust anti-inflammatory action by inhibiting nitric oxide (NO) production, suppressing iNOS gene expression, and reducing the release of pro-inflammatory cytokines such as PGE2, IL-6, and IL-8 in human normal fibroblast cell lines. Furthermore, it acts as an antioxidant, effectively neutralizing harmful free radicals like DPPH and safeguarding human erythrocytes from oxidative damage. The extract also supports cellular health, showing a 10% to 60% increase in cell viability against LPS. Additionally, it exhibits antimicrobial properties against various fungal and bacterial pathogens, and its component norgalanthamine may contribute to hair growth by inhibiting 5α-reductase activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Complete inhibition of IL-8 release in human normal fibroblast cell lines observed at concentrations greater than 0.0025%.
  2. 02 Almost complete inhibition of PGE2 release in human normal fibroblast cell lines observed at concentrations greater than 0.05%.
  3. 03 Inhibitory activity of nitric oxide (NO) production in LPS-activated mouse macrophage RAW 264.7 cells, with an IC50 of 58.5 μg/ml for the ethanol extract.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While no formal CIR, SCCS, or FDA safety review status is available, human clinical testing involving repeated epicutaneous patch applications showed no cumulative irritation or sensitization, indicating good topical safety. However, the plant is commonly known as 'poison bulb,' and all parts are considered toxic if ingested, primarily due to alkaloids like lycorine, which can cause emetic effects. Direct exposure to the raw plant's sap may cause skin irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Crinum Asiaticum Root Extract is a valuable multi-functional ingredient offering significant anti-inflammatory, antioxidant, and skin-conditioning benefits across all skin types with a low risk of irritation or comedogenicity.

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