CREPIDIASTRUM DENTICULATUM LEAF/STEM EXTRACT.

Crepidiastrum Denticulatum Leaf/Stem Extract operates by significantly decreasing oxidative stress and robustly inhibiting the production of pro-inflammatory cytokines, which collectively serves to reduce or delay cellular senescence. It activates autophagy, a crucial cellular process that enables skin cells to remove damaged components and improve overall function. The extract actively combats pollution-induced skin aging caused by environmental toxins such as car exhaust, heavy metals, and airborne particulates. It decreases matrix metalloproteinase (MMP) expression, which can degrade collagen, while simultaneously increasing collagen expression and synthesis to support skin structure. Furthermore, it enhances antioxidant enzyme expression to effectively down-regulate reactive oxygen species (ROS). The primary active compounds include flavonoids (such as quercetin, kaempferol, luteolin, and apigenin), phenolic acids (like chlorogenic acid and caffeic acid), and sesquiterpene lactones, which contribute to its antioxidant, anti-inflammatory, and anti-microbial properties.