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Moumoujus

COUMAROYL SH-PENTAPEPTIDE-5.

Valuable / ANTIOXIDANT, SKIN PROTECTING

COUMAROYL SH-PENTAPEPTIDE-5 is a precision peptide engineered to address visible expression lines and deep wrinkles through a 'Botox-like' mechanism. It further stimulates the skin's natural regeneration, enhancing elasticity, and fortifying the skin barrier for a smoother, firmer, and more resilient complexion.

Summary

antioxidant skin protecting skin conditioning anti-aging wrinkle reduction muscle relaxation skin regeneration elasticity enhancement skin barrier improvement hydrating skin firming texture improvement

Science

Mechanism of Action

This ingredient is related to sh-Pentapeptide-5, a synthetic recombinant peptide that acts as an analog of human Leu-Enkephalin, mimicking natural endorphin activity. Its primary 'Botox-like' action involves interaction with delta-opioid receptors at the neuromuscular synaptic junction in facial muscles. This interaction induces a hyperpolarizing effect on the presynaptic neuron, thereby inhibiting the release of acetylcholine. The resulting muscle relaxation visibly reduces expression lines and deep wrinkles. Additionally, COUMAROYL SH-PENTAPEPTIDE-5 facilitates an Epidermal Growth Factor (EGF)-like effect, promoting crucial skin regeneration and repair processes, which subsequently improves skin texture, resilience, and barrier function.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No dedicated Cosmetic Ingredient Review (CIR) report, SCCS opinion, or FDA status has been identified specifically for COUMAROYL SH-PENTAPEPTIDE-5. While CIR reports exist for other pentapeptides, this specific variant lacks a formal review. Industry sources, such as Paula's Choice, categorize it as 'not rated' due to insufficient reviewed research.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

COUMAROYL SH-PENTAPEPTIDE-5 is a valuable peptide for addressing expression lines and promoting comprehensive skin rejuvenation, supported by a well-defined mechanism of action and promising, albeit indirectly, clinical data.

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