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Moumoujus

COTINUS COGGYGRIA BRANCH/LEAF OIL.

Questionable CAS 89997-96-6 / FLAVOURING, FRAGRANCE, PERFUMING

Cotinus Coggygria Branch/Leaf Oil is a botanical extract celebrated for its diverse biological activities, including significant antioxidant, anti-inflammatory, and antimicrobial properties. It also holds potential for refining skin texture, enhancing elasticity, and promoting a more even skin tone, though its potent nature requires careful formulation and dilution.

Summary

Antioxidant Anti-inflammatory Antimicrobial Astringent Skin Lightening Elasticity Support Hair Growth Promotion Masking Perfuming

Science

Mechanism of Action

This oil functions as a potent antioxidant by actively inhibiting oxygen-favored reactions and scavenging free radicals, thereby protecting skin cells from oxidative stress and potential UV radiation damage (specifically Spectrum B). It possesses astringent qualities, which can visually tighten pores, contributing to a smoother skin appearance. Recognized for its antiseptic, antibacterial, and antifungal actions, it helps to mitigate microbial growth and soothe inflammation, supporting the skin's natural healing processes. Furthermore, it may contribute to improved skin elasticity and resilience through the inhibition of collagenase and elastase, and offers potential for skin lightening by inhibiting tyrosinase activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated strong antioxidant activity, with essential oil and various extracts showing high DPPH radical scavenging potential (e.g., IC50 values as low as 1.7 µg/ml for ethyl acetate fraction and 2.6-3.8 µg/ml for methanol extracts).
  2. 02 Exhibited effective antimicrobial properties against Gram-positive and Gram-negative bacteria (MIC 25-200 µg/ml for acetone extract and ethyl acetate fraction) and the yeast Candida albicans (MIC 3.12 µg/ml for chloroform fraction).
  3. 03 Showed in-vitro anti-inflammatory activity in the essential oil (IB50 of 12.3 ± 0.3 µL).
  4. 04 Extracts have been studied for their potential to inhibit key enzymes like collagenase, elastase, and tyrosinase, suggesting benefits for maintaining skin structure, elasticity, and achieving skin lightening effects.
  5. 05 An aqueous extract was found to effectively induce hair growth when applied topically in vivo.

Transparency

Dusting Analysis

Not commonly dusted

This ingredient is an oil, and the concept of 'dusting' typically applies to active ingredients present in very low concentrations, which is not relevant here.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Conflicts

  • Should not be applied undiluted to the skin due to its highly concentrated nature.
  • Requires dilution with carrier oils (e.g., almond, cocoa, olive oils) for safe topical application.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

This ingredient has not undergone safety review by authoritative bodies such as CIR, SCCS, or FDA. Safety data sheets indicate a significant risk, classifying it as 'Causes skin irritation' (Category 2) and 'May cause an allergic skin reaction' (Category 1). Due to these risks, it is imperative to use this oil in diluted form. The IFRA Code of Practice recommends usage levels up to 2.0000% in fragrance concentrates, providing a benchmark for caution in formulations.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While Cotinus Coggygria Branch/Leaf Oil presents a broad spectrum of promising benefits for skin health, its unreviewed safety status and documented risks of skin irritation and allergic reactions necessitate extreme caution, rendering its inclusion in precision skincare formulations questionable without rigorous, specific safety and efficacy validation at appropriate dilutions.

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