Science
Mechanism of Action
The extract's mechanism of action involves the established anti-inflammatory and soothing attributes of both Corydalis yanhusuo and Leonurus japonicus. Notably, Corydalis yanhusuo has been shown to inhibit mast cell activation through the PLC/PKC/STAT3 pathway, indicating a targeted anti-allergic response that contributes to reducing skin reactivity and inflammatory markers.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Extracts from Corydalis yanhusuo are typically prepared using hot water. The solubility of its active alkaloids can be enhanced by processing with vinegar.
Safety
Safety Profile
No specific topical cosmetic safety assessments from regulatory bodies such as CIR, SCCS, or FDA are available for this combined extract. While generally considered safe for topical use, patch testing is advised for individuals with sensitive skin, as potential allergic reactions may occur in those sensitive to plants from the same botanical family. It is crucial to note that for oral consumption, Corydalis yanhusuo is deemed likely unsafe during pregnancy and breastfeeding due to its berberine content, which can induce uterine contractions, potentially harm the fetus, and cause brain damage in infants. Oral use may also interfere with blood clotting and blood sugar control during surgical procedures. Excessive oral doses exceeding 3 g/day have been associated with minor toxicity, including liver concerns. These oral safety profiles should be carefully considered, particularly for vulnerable populations, even in topical applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This extract offers promising soothing and anti-inflammatory benefits for sensitive skin, but the current absence of specific topical clinical efficacy data and comprehensive safety reviews from cosmetic regulatory bodies necessitates cautious formulation and application, especially given the significant oral safety concerns associated with one of its components.
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References
Sources