Science
Mechanism of Action
This extract functions through several key pathways. As a robust antioxidant, it effectively neutralizes free radicals, thereby shielding the skin from oxidative stress and mitigating age-related damage. Its significant anti-inflammatory capabilities stem from inhibiting pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), TNF-α, IL-8, and other cytokines, while also attenuating NF-κB activation to calm irritation and redness. Beyond soothing, Cornus Officinalis Fruit Extract is indicated to stimulate collagen production, enhancing skin elasticity and diminishing the appearance of fine lines. It further supports skin's natural moisture balance, aids in cell membrane protection, promotes regeneration for a vibrant appearance, and can contribute to a brighter skin tone by inhibiting tyrosinase, thereby reducing melanin synthesis. Some evidence also suggests a role in gentle exfoliation.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In vitro studies show 71.3-96.9% inhibition of nitric oxide (NO) and prostaglandin E2 (PGE2) production at concentrations of 1-100 µg/mL.
- 02 An aqueous-methanolic extract decreased IL-8 secretion by neutrophils to 49.68-54.64% compared to LPS-stimulated controls at 5-100 µg/mL.
- 03 Aqueous extract significantly inhibited TNF-α release from neutrophils at 50-100 µg/mL.
- 04 At 100 µg/mL, it increased mRNA/protein levels of KLF2 and eNOS, and decreased mRNA/protein/biomarker levels of MCP-1, ICAM-1, VCAM-1, alongside reduced p38 phosphorylation, indicating anti-inflammatory effects.
- 05 Demonstrated anti-allergic activity by inhibiting β-hexosaminidase release from RBL-2H3 cells with an IC50 of 0.178 mg/mL.
- 06 Exhibited concentration-dependent antioxidant activity: DPPH radical scavenging with an EC50 of 1.82 mg/mL (within a 0.1-10 mg/mL range) and ABTS scavenging with an EC50 of 0.60 mg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The ingredient is chemically stable under standard ambient conditions (room temperature).
Safety
Safety Profile
While formal safety assessments by CIR or SCCS are not available, Cornus Officinalis Fruit Extract has a history of widespread traditional use in food and medicine, suggesting a generally good safety profile. SkinSAFE rates it as 'Safe when used as intended,' and EWG Skin Deep identifies low concerns for cancer, allergies & immunotoxicity, and developmental & reproductive toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cornus Officinalis Fruit Extract is a highly valuable ingredient for its robust antioxidant, anti-inflammatory, and multifaceted skin-conditioning properties, making it suitable for a wide range of precision skincare formulations targeting aging, irritation, and overall skin health.
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