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Moumoujus

CORNUS MAS EXTRACT.

Valuable / SKIN CONDITIONING

Cornus Mas Extract is a botanical active recognized for its comprehensive benefits, including potent antioxidant and anti-inflammatory properties. It actively supports skin regeneration by enhancing keratinocyte and fibroblast viability, contributing to improved skin resilience and a more even tone.

Summary

Antioxidant Anti-inflammatory Cell Proliferant Anti-aging Antimicrobial Toning Astringent Exfoliant Cytoprotective

Science

Mechanism of Action

Cornus Mas Extract functions as a powerful antioxidant by significantly reducing intracellular reactive oxygen species (ROS) and regulating genes involved in oxidative stress, such as SOD-1 and Nox-4. It exhibits anti-inflammatory effects through the suppression of pro-inflammatory cytokines like IL-6, IL-8, and TNF-α, and by activating the PPARγ/PGC-1α pathway to mitigate skin irritation. The extract also promotes anti-aging and proliferative actions by stimulating keratinocyte and fibroblast growth, inhibiting elastase and collagenase activity, and providing defense against UV-induced photoaging. Additionally, it possesses antimicrobial capabilities against certain pathogenic bacteria and offers toning and astringent benefits, with its iridoid glycosides potentially aiding in the gentle removal of dead skin cells.

Research

Clinical Evidence

Medium confidence
Effective range 1–10%
Optimal

5%

Key findings

  1. 01 In vitro studies indicate that a 1% concentration stimulates keratinocyte migration, crucial for skin repair and renewal.
  2. 02 Positive effects on the viability of human keratinocytes and fibroblasts were observed at concentrations of 1.0% and 5.0% in vitro.
  3. 03 At 10% concentration, the extract demonstrated cytoprotective properties for human skin fibroblasts and keratinocytes in vitro.
  4. 04 Significant free radical scavenging activity, up to 67%, was demonstrated in vitro at a 1:20 v/v dilution, highlighting its antioxidant potential.
  5. 05 In vitro testing of oil fractions up to 50% (V/V) showed no adverse effect on fibroblast viability, suggesting a low risk of irritation.

Transparency

Dusting Analysis

Not commonly dusted

No data suggests this ingredient is commonly used at ineffective concentrations. Efficacy has been observed across a range of in vitro concentrations from 1% to 10% for cellular benefits.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Extracts are noted to contribute to the formation of stable dispersed systems within cosmetic emulsions, enhancing product integrity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No official safety assessments by CIR, SCCS, or FDA were found. However, in vitro studies utilizing oil fractions up to 50% indicated no cellular irritation, suggesting a low risk for skin sensitivity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Cornus Mas Extract presents valuable antioxidant, anti-inflammatory, and pro-regenerative properties in vitro, making it a promising ingredient for comprehensive skin support and resilience.

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