Science
Mechanism of Action
This extract primarily acts as an antioxidant by reducing intracellular reactive oxygen species (ROS) accumulation. Its robust anti-inflammatory effects are mediated through the inhibition of NF-κB and MAPK signaling pathways, activation of AMP-activated protein kinase (AMPK), and suppression of nitric oxide production by downregulating inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). It additionally serves as a skin conditioning agent, potentially offering astringent and emollient properties.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies on LPS-stimulated RAW 264.7 macrophages demonstrated significant dose-dependent anti-inflammatory activity without cytotoxicity, even at high concentrations. These studies observed a reduction in nitric oxide production, attenuated intracellular reactive oxygen species accumulation, and downregulated expression of iNOS and COX-2. Furthermore, inhibition of NF-κB p65 phosphorylation and decreased levels of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, were noted.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments by major regulatory bodies such as the Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or Food and Drug Administration (FDA) were identified. Paula's Choice currently lists it as 'Not rated' and a 'new ingredient', suggesting limited comprehensive safety reviews to date.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cornus controversa extract is a valuable botanical offering potent anti-inflammatory and antioxidant benefits, making it highly suitable for soothing and protecting a wide range of skin types with a low risk of irritation or comedogenicity.
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References
Sources