Science
Mechanism of Action
This extract's efficacy stems from its diverse phytochemical composition. Polyphenols and flavonoids are key contributors to its antioxidant capacity, demonstrated by 100% DPPH radical scavenging, and provide anti-inflammatory and antimicrobial benefits. Alkaloids further support these anti-inflammatory, antioxidant, and antibacterial actions. Additionally, saponins present within the extract may facilitate enhanced penetration of other active ingredients into the skin.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A methanolic extract of Cordyline terminalis, at a concentration of approximately 10% (100 µg/µl), exhibited moderate antibacterial activity. It generated inhibition zones of 12mm against *Escherichia coli* and *Staphylococcus epidermis*, 14mm against *Shigella boydii*, and 13mm against *Streptococcus pyogenes*.
- 02 Aqueous Cordyline terminalis extract, encapsulated within supramolecular gels at concentrations ranging from 3.1 to 12.5 mg/mL, achieved 100% scavenging of the DPPH radical, indicating significant antioxidant capacity.
- 03 In *in-vitro* cytotoxicity assessments, the aqueous Cordyline terminalis extract in supramolecular gels demonstrated excellent biocompatibility, maintaining cell viability above 85%.
Transparency
Dusting Analysis
There is no data to suggest Cordyline Terminalis Leaf Extract is commonly 'dusted' or used at ineffective concentrations. Clinical data indicates efficacy at measurable concentrations in *in-vitro* studies.
The Formula
Formulation
Stability
The extract's color is highly sensitive to pH, transitioning from bright green at pH 7.2 to red around pH 5.4, and dull green in alkaline conditions, which could impact product aesthetics. Its bioactive compounds may also exhibit instability under physiological conditions, suggesting that advanced formulation techniques like encapsulation could enhance their efficacy and shelf-life.
Synergies
- Enhanced penetration of other active ingredients when formulated alongside, due to the presence of saponins.
Conflicts
- High concentrations of the extract should be avoided due to the presence of potentially harmful compounds such as saponins, coumarins, and cardiac glycosides.
- Significant pH shifts within a formulation will result in noticeable color changes.
Safety
Safety Profile
Comprehensive safety assessments by regulatory bodies such as CIR, SCCS, or FDA for cosmetic application are currently lacking. The extract contains compounds including saponins (potential for hemolysis), coumarins (potential anti-coagulant effect), and cardiac glycosides (potential toxicity), which carry risks if utilized at high dosages. Despite these concerns, *in-vitro* studies of an aqueous extract in gel formulations demonstrated non-cytotoxicity with cell viability exceeding 85%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cordyline Terminalis Leaf Extract demonstrates promising *in-vitro* antimicrobial, antioxidant, and anti-inflammatory properties, but requires further comprehensive safety and efficacy data for direct human skin application, particularly concerning optimal concentrations and potential toxicity from specific phytochemicals.
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References
Sources