Science
Mechanism of Action
This extract mitigates inflammation through multiple pathways. Its butanol fraction has been shown to reduce histamine release, IgE production, and the secretion of key inflammatory cytokines such as IL-4 and IFN-γ. Additionally, 1,9-dimethylguanine, an active compound, inhibits NF-κB and AP-1 activity, thereby suppressing the expression of inflammatory mediators like COX-2 and TNF-α.
Research
Clinical Evidence
Medium confidence2%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Active compounds of Cordyceps bassiana are primarily water-soluble, with a butanol fraction also studied, indicating solubility in polar organic solvents. While specific optimal pH is not established, related Cordyceps militaris polysaccharide extracts have shown compatibility in cream bases at approximately pH 4.45.
Safety
Safety Profile
Specific safety reviews by CIR, SCCS, or FDA for Cordyceps bassiana extract are not currently available. However, safety data from related Cordyceps species suggests a low risk profile; for example, a Cordyceps militaris polysaccharide cream was confirmed safe in 20 female volunteers, and Cordyceps sinensis crude extracts demonstrated safe use up to 1% in fibroblast cell lines.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cordyceps Bassiana Extract is a valuable ingredient for advanced skincare formulations, particularly those addressing inflammatory conditions and compromised skin, substantiated by preclinical evidence of its anti-atopic and immunomodulatory effects.
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References
Sources