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Moumoujus

COPTIS CHINENSIS ROOT EXTRACT.

Insufficient Data / ANTIOXIDANT

Coptis Chinensis Root Extract is a botanical powerhouse, celebrated for its significant antioxidant and anti-inflammatory properties, effectively calming the skin and reducing redness. Rich in beneficial alkaloids like berberine and coptisine, it helps regulate skin microflora, bolstering the skin's natural defenses against external irritants.

Summary

Antioxidant Soothing Antimicrobial Skin-Conditioning Moisturizer Sebum Regulation

Science

Mechanism of Action

This extract exerts its dermatological benefits through a multifaceted approach, primarily via its potent alkaloid composition, including berberine, coptisine, palmatine, and epiberberine. It actively downregulates pro-inflammatory pathways and signaling molecules, while demonstrating broad-spectrum antimicrobial activity against harmful bacteria and fungi. Beyond its soothing actions, it aids in maintaining skin hydration, supports natural regeneration processes, and can modulate sebum production, making it versatile for various skin concerns.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Fractionated Coptis chinensis extract and its key component, berberine, effectively suppressed Propionibacterium acnes-stimulated inflammation in human keratinocytes, indicating potential for acne management.
  2. 02 Key constituents, berberine and coptisine, demonstrated potential for rosacea treatment by downregulating kallikrein 5 (KLK5) and cathelicidin, inhibiting KLK5 protease activity, and reducing pro-inflammatory cytokines in human epidermal keratinocytes.
  3. 03 In vitro studies with coptisine (0-25 μmol/L) showed inhibition of cell viability, adhesion, and migration in HCT116 cells, alongside modulation of EMT markers and induction of apoptosis, suggesting cellular regulatory properties.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Coptis Chinensis Root Extract is readily soluble in water and alcohol. Its primary active compounds, alkaloids, exhibit high solubility in acidified polar solvents. Formulators should note its characteristic yellow color, predominantly due to berberine, as a potential aesthetic consideration.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has designated Coptis Chinensis Root Extract with 'Insufficient Data,' necessitating further safety evaluation if its use continues. The Scientific Committee on Consumer Safety (SCCS) has not evaluated this ingredient, though it is not restricted in the EU. The EWG Skin Deep database generally rates concerns for cancer, allergies & immunotoxicity, and developmental/reproductive toxicity as 'LOW'. While typically non-irritating, it may cause irritation when combined with other problematic ingredients according to some sources.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Insufficient Data

Coptis Chinensis Root Extract presents significant potential for its antioxidant, anti-inflammatory, and antimicrobial skin benefits, though a CIR status of 'insufficient data' indicates a need for more comprehensive safety assessments.

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