Science
Mechanism of Action
Coprinus Comatus Extract acts through its rich composition of bioactive compounds, including polysaccharides, lectins, and various antioxidants. This potent blend delivers robust antioxidant protection, effectively neutralizing free radicals and mitigating oxidative stress, thereby addressing premature aging signs like fine lines and wrinkles. Its anti-inflammatory components work to calm skin, reducing redness and irritation. Furthermore, specific constituents within the extract are thought to bolster skin hydration and support the epidermal barrier's moisture retention capabilities.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated effective superoxide radical scavenging with an IC50 of 1.03 mg/mL in vitro.
- 02 Exhibited strong hydroxyl radical scavenging activity with an IC50 of 0.66 mg/mL in vitro.
- 03 Achieved greater than 77.2% DPPH radical scavenging activity in vitro at concentrations ranging from 4-8 mg/mL.
- 04 An ethanol extract showcased a 63.4% antioxidant effect at a concentration of 1 mg/mL in vitro.
- 05 A hot water extract displayed a 65.6% antioxidant effect at a concentration of 5 mg/mL in vitro.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The mushroom itself rapidly undergoes autolysis after harvesting. For cosmetic use, hot water extraction is a common method to concentrate its water-soluble polysaccharides, suggesting this approach is key for extracting stable and effective compounds. Specific stability data for the extract within cosmetic formulations is not detailed.
Safety
Safety Profile
There are no specific safety assessments from regulatory bodies such as CIR, SCCS, or FDA for the topical cosmetic use of Coprinus Comatus Extract. However, patch tests using protein from the mushroom cap (5 mg protein per 1 g vaseline) or spores (1.35 mg protein per 1 g vaseline) induced delayed-type skin reactions in patients with atopic dermatitis and those with atopic predisposition. This indicates a potential for sensitization or irritation, particularly in sensitive or compromised skin types.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting promising in-vitro antioxidant efficacy and potential for skin conditioning, the documented capacity to induce delayed-type skin reactions in atopic individuals presents a significant safety consideration, making its universal recommendation for a precision brand questionable without further comprehensive safety data.
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References
Sources