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COPPER AMINOACETYLAMINOIMIDAZOLYL PROPANOATE.

Valuable / SKIN CONDITIONING

A high-performance bio-energy peptide complex engineered to revitalize aging skin by supplying essential copper and amino acids directly to fibroblasts. It acts as a needle-free structural filler, rapidly re-energizing the skin’s natural production of collagen and elastin for visible firming.

Cell-communicating ingredient Skin conditioning Collagen booster Anti-inflammatory

Science

This molecule functions by reactivating senescent (dormant) fibroblasts, which are the skin's primary collagen and elastin factories. It delivers a source of bio-available copper to activate lysyl oxidase—an enzyme essential for the cross-linking and maturation of structural proteins—while providing lysine and proline as building blocks for the synthesis of Collagen I (+179%), Collagen III (+194%), and Elastin (+190%).


Research

High confidence
Effective range 0.5–1%
Optimal

1%

Key findings

  1. 01 A 0.5% concentration increased total collagen by 6.8% and elastin production by 190% within 11 days compared to untreated skin.
  2. 02 A 1.0% concentration in a double-blind study demonstrated a significant reduction in wrinkle depth and volume over a 15-day period.

Transparency

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

Due to its high cost and potent clinical data, many brands include this ingredient at trace levels purely for label claims. Concentrations below 0.5% are unlikely to trigger the rapid structural protein synthesis observed in clinical trials.


The Formula

Solubility
Water
Optimal pH 3 – 7
0 7 14

Stability

Highly temperature-sensitive; must be formulated below 45°C to maintain peptide integrity. It is incompatible with low-pH environments.

Synergies

  • Hyaluronic Acid
  • Glycerin
  • Non-acidic peptides

Conflicts

  • L-Ascorbic Acid
  • Retinoids
  • Alpha Hydroxy Acids (AHAs)
  • Beta Hydroxy Acids (BHAs)

Safety

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

While not specifically reviewed by the CIR, its related compound, Copper Gluconate, is FDA GRAS (Generally Recognized As Safe). Patch testing is recommended for those with hyper-sensitive skin due to the potential for minor irritation with copper-based actives.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An exceptional precision-aging active that delivers rapid, measurable improvements in skin density and elasticity, provided it is formulated at a clinical concentration of at least 0.5%.


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