Science
Mechanism of Action
This resin oil primarily exerts its beneficial effects through its high concentration of beta-caryophyllene, a compound known to interact with cannabinoid receptors within the skin. This interaction stimulates skin cells to produce beta-endorphins, contributing to a profound soothing sensation. It precisely modulates inflammatory processes by decreasing the recruitment of inflammatory cells and inhibiting macrophage activity. On the skin, it aids in regulating sebum production, effectively unclogging pores, and addressing concerns like acne and blackheads, acting as a gentle, non-irritating alternative to retinol. Additionally, it minimizes redness, provides moisturizing benefits, and acts as a protective film on the skin.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Oral administration of 400 mg/kg of copaiba oil-resin for 7 days modulated the inflammatory process by significantly decreasing the recruitment of inflammatory cells. It also reduced motor cortex damage by 39% and neutrophil infiltration in acute neural disorders.
- 02 Demonstrated significant antiprotozoal activity against *Leishmania amazonensis*, with an IC50 of 5.0 µg/mL for the promastigote form and 15.0 µg/mL for the amastigote form after 72 hours of incubation.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR) has not assessed this ingredient, the FDA has approved Copaiba oil-resin as a flavoring agent or adjuvant (21 CFR 172.5106), generally recognizing it as non-toxic and a safe food additive. Topically, it is regarded as one of the safest oils for skin use, known to promote healing and soothe irritation. However, individual sensitivities can occur; therefore, proper dilution with a carrier oil and a preliminary patch test are recommended before widespread application. Oral ingestion of high doses (e.g., 10g) has been associated with adverse gastrointestinal effects and, with prolonged use, potential kidney damage, but these concerns are specific to oral, not topical, application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Copaifera Reticulata Resin Oil is a valuable ingredient, offering broad anti-inflammatory, soothing, and skin-balancing benefits with low irritancy and comedogenicity, making it highly suitable for all skin types.
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