Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

COMMIPHORA MYRRHA OIL.

Valuable CAS 84929-26-0 / FRAGRANCE, SKIN CONDITIONING, TONIC

Commiphora Myrrha Oil is a multifaceted botanical extract recognized for its comprehensive action against various skin concerns. It actively reduces inflammation, inhibits bacterial proliferation, and provides antioxidant protection against environmental stressors. Furthermore, it supports skin regeneration and offers potential relief from itch through specific mast cell pathway modulation.

Summary

Antimicrobial Anti-inflammatory Antioxidant Astringent Wound healing Skin regenerating Masking Skin conditioning Tonic

Science

Mechanism of Action

Commiphora Myrrha Oil exerts its effects through several biological pathways. It exhibits broad-spectrum antimicrobial activity by compromising the integrity of bacterial cell walls and membranes, effective against bacteria such as *Propionibacterium acnes*, *Staphylococcus aureus*, and *Pseudomonas aeruginosa*, as well as antifungal actions against *Candida albicans*. Its potent anti-inflammatory properties stem from the inhibition of key mediators including prostaglandin E2, nitrous oxide, and pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-8), alongside a notable suppression of IL-31 production and histamine release from mast cells, which directly addresses itch. As an antioxidant, it actively neutralizes free radicals and reactive oxygen species, safeguarding cellular structures from oxidative stress. Additionally, it possesses astringent qualities to modulate sebum production and promotes skin regeneration by stimulating collagen synthesis, thereby aiding in the repair of compromised skin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In human mast cells (HMC-1), a Commiphora myrrha extract at concentrations ranging from 25-100 µg/ml significantly suppressed phorbol myristate acetate and calcium ionophore-stimulated mRNA expression. This activity reduced the production of IL-31 and prevented histamine release without inducing cytotoxicity up to 100 µg/ml, indicating a potential role in itch management.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Commiphora Myrrha essential oil may solidify or crystallize at room temperature; this is a reversible physical change that does not compromise its quality or efficacy and can be reversed by gentle warming.

Conflicts

  • Stitches (especially silk ones) may exhibit degradation upon exposure to myrrh, though concentrations typically found in mouthwash products showed no adverse effects.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Moderate

While Commiphora Myrrha Oil is listed on the FDA's Generally Recognized As Safe (GRAS) list for food flavoring, topical application warrants careful consideration. It carries a risk of skin irritation, allergic reactions, and photosensitivity, particularly if used undiluted or in excessive amounts. A patch test is strongly recommended prior to use, and proper dilution with a carrier oil is crucial. Prolonged sun exposure should be avoided when using products containing this ingredient. Pregnant or breastfeeding individuals should consult a healthcare professional before incorporation into their regimen.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Commiphora Myrrha Oil is a valuable ingredient, offering broad benefits from antimicrobial and anti-inflammatory action to itch relief and wound healing, provided formulation takes into account its moderate irritancy and potential photosensitivity.

Related

Similar Ingredients

Finding similar ingredients…