Science
Mechanism of Action
This extract operates as a sophisticated plumping agent by stimulating lipogenesis and simultaneously reducing lipolysis, thereby augmenting the skin's natural lipid synthesis to visibly fill wrinkles. Its comprehensive anti-aging action involves promoting fibroblast proliferation and increasing collagen type I synthesis. Furthermore, it effectively inhibits matrix metalloproteinase-1 (MMP-1) and elastase expression, enzymes responsible for degrading skin's structural proteins. Beyond these actions, the ingredient offers anti-inflammatory, rejuvenating, toning, and antioxidant benefits, coupled with antiseptic, astringent, disinfectant, and antibacterial effects that can be particularly advantageous for acne-prone or irritated skin conditions.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies on CCL-110 skin fibroblast cell lines demonstrated a dose-dependent inhibition of matrix metalloproteinase-1 (MMP-1) expression and over 50% inhibition of human elastase expression, indicating significant anti-wrinkle properties at concentrations of 20-100 μg mL⁻¹.
- 02 A face cream incorporating Commiphora Mukul improved skin hydration and elasticity in human volunteers without eliciting irritation.
- 03 An experimental study revealed that Commiphora Mukul gum extract enhanced VEGF and notably improved skin elasticity, accelerating wound healing by significantly reducing wound area within 7 days.
Transparency
Dusting Analysis
No data available to suggest dusting concerns for this ingredient.
The Formula
Formulation
Stability
Formulated products containing Commiphora Mukul Resin Extract exhibit good stability, particularly within an ideal pH range of 5.5 to 6.5.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) and the Scientific Committee on Consumer Safety (SCCS) have not specifically evaluated Commiphora Mukul Resin Extract. While the FDA does not provide specific approval or denial for cosmetic ingredients, and no specific FDA cosmetic status is found, one source indicates 'no known hazards to humans or the environment associated with this product.' A formulated cream containing this extract was reported to not cause irritation in human volunteers.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Commiphora Mukul Resin Extract is a valuable ingredient, demonstrating significant anti-aging, plumping, and skin reparative properties, suitable for a broad range of skin types without reported irritation in a formulated product.
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