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COMMIPHORA GILEADENSIS SAP EXTRACT.

Valuable / ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, UV FILTER

Commiphora Gileadensis Sap Extract is a versatile botanical ingredient derived from the sap of the Balm of Gilead tree, revered for its potent medicinal properties. Rich in polyphenols and flavonoids, this extract offers a comprehensive range of benefits including antioxidant, anti-inflammatory, and protective effects against environmental stressors, while also showing targeted action on abnormal skin cell proliferation.

Summary

Antioxidant Antimicrobial Anti-inflammatory UV Filter Astringent Soothing Tonic Wound Healing Support Cell Cycle Regulator (Selective Apoptosis Inducer)

Science

Mechanism of Action

This extract functions as a powerful antioxidant, shielding skin cells from oxidative stress. It exhibits significant antimicrobial properties by inhibiting bacterial growth and blocking lectins. Anti-inflammatory effects are achieved through cyclooxygenase inhibition. Furthermore, it offers UV protection by reducing UVB-induced caspase-3 activity and safeguarding cellular DNA. Notably, it can selectively induce cell cycle-dependent apoptosis in hyperproliferating skin cells, such as immortalized keratinocytes and human dermoid carcinoma cells, without harming normal fibroblasts. It also provides tonic, soothing, and astringent benefits, supporting overall skin health and aiding in wound recovery.

Research

Clinical Evidence

Medium confidence
Effective range 1–2%
Optimal

1.5%

Transparency

Dusting Analysis

Not commonly dusted

No data available in the provided research to suggest this ingredient is commonly 'dusted' or used at ineffective levels for marketing claims.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

A commercially available form is a 20% solution stabilized in water and glycerin. Specific optimal pH ranges for stability in finished cosmetic formulations were not identified in the research.

Synergies

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Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No dedicated safety assessments by major regulatory bodies (CIR, SCCS, FDA) were found for Commiphora Gileadensis Sap Extract. Traditional accounts of the resin's internal use suggest moderation. However, in vitro studies indicate a beneficial selective cytotoxicity, targeting hyperproliferating cells while demonstrating protective effects on normal fibroblasts, which suggests favorable tolerability for normal skin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Commiphora Gileadensis Sap Extract is a valuable botanical active, offering a broad spectrum of benefits including potent antioxidant, anti-inflammatory, and UV protective qualities, alongside promising selective action against abnormal skin cell proliferation.

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