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COMMIPHORA GILEADENSIS BRANCH/FRUIT/LEAF EXTRACT.

Valuable / ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, UV FILTER

Commiphora gileadensis Branch/Fruit/Leaf Extract is a multi-functional botanical ingredient recognized for its potent protective and restorative properties. It demonstrably shields skin from UV-induced damage, provides significant antioxidant defense, and offers antimicrobial and anti-inflammatory benefits, making it valuable for comprehensive skin health.

Summary

Antioxidant Skin-soothing Antimicrobial UV Protectant Wound healing Anti-inflammatory

Science

Mechanism of Action

This extract operates through several pathways to support skin health. It acts as a UV protectant by significantly reducing UVB-induced caspase-3 activity, a key marker of cellular apoptosis, and by safeguarding cellular DNA from UV damage. Its rich content of phenolic compounds confers potent antioxidant capabilities, effectively neutralizing free radicals. Furthermore, the extract exhibits traditional anti-inflammatory actions and demonstrates antimicrobial efficacy against common skin bacteria such as Bacillus cereus, Staphylococcus aureus, and Pseudomonas aeruginosa, which collectively contribute to its wound-healing potential and overall skin barrier support.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Commiphora gileadensis extracts, derived from various plant parts, were shown to reduce UVB-induced caspase-3 activity and protect DNA from UV damage in skin tissue samples. This protective effect was observed both before and after UV exposure, with enhanced efficiency when delivered via an oily carrier.
  2. 02 Human skin explants treated topically with increasing concentrations of C. gileadensis hydrosol 24 hours prior to UVB irradiation exhibited decreased levels of caspase-3 activity 24 hours post-irradiation.
  3. 03 An in vitro radical-scavenging test demonstrated 77.8% antioxidant activity from C. gileadensis extracts at a concentration of 100 μg/mL.
  4. 04 Leaf extract displayed a maximum of 51.6% scavenging activity for hydrogen peroxide hydrolysis at a final concentration of 2.5 mg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Synergies

  • Enhanced efficacy against UVB damage when combined with an oily carrier.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

An acute oral toxicity study in rats with a methanolic-aqueous extract showed no deaths or statistically significant differences in body weights between treated and control groups, suggesting potential safety at administered doses. However, rats initially showed reluctance to ingest food and water, alongside signs of anesthesia, during the first four hours post-administration. Dermal toxicity for the bud extract specifically has not been determined.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Commiphora gileadensis Branch/Fruit/Leaf Extract is a valuable multi-functional ingredient offering significant UV protection, potent antioxidant activity, and antimicrobial benefits for overall skin health and resilience.

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