Science
Mechanism of Action
This extract operates through a multifaceted mechanism, primarily by modulating the Nuclear Factor-κB (NF-κB) pathway in skin cells, which effectively diminishes pro-inflammatory responses. It significantly reduces the synthesis of nitric oxide (NO) and downregulates key inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Furthermore, its rich composition of phytochemicals, including flavonoids (e.g., glucoluteolin, orientin, isoorientin, isoquercitrin) and squalene, provides potent antioxidant activity by neutralizing free radicals. The presence of p-hydroxycinnamic acid also confers antibacterial benefits. As a humectant, it actively helps the skin attract and retain moisture, enhancing overall hydration and barrier function.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 An in vitro study utilizing murine macrophages demonstrated that Commelina Communis Extract at a concentration of 1.5 mg/mL significantly reduced inflammation. This effect was achieved by modulating the Nuclear Factor-κB pathway, leading to a decrease in nitric oxide synthesis and a reduction in pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6. Notably, cell viability remained above 99% at this concentration, indicating excellent cellular compatibility.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As a plant extract, its stability is generally influenced by external factors such as oxygen, temperature, moisture, and light, necessitating careful storage and formulation.
Safety
Safety Profile
No specific safety assessments by CIR or SCCS were found. However, in vitro studies indicated low cytotoxicity, maintaining cell viability above 99% at concentrations up to 1.5 mg/mL. It is generally considered non-irritating.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Commelina Communis Extract is a valuable ingredient, offering precise anti-inflammatory and antioxidant benefits, coupled with hydration and protective properties, making it highly beneficial for maintaining healthy, resilient skin.
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