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Moumoujus

COMBRETUM MICRANTHUM LEAF EXTRACT.

Valuable CAS 84776-30-7 / SKIN CONDITIONING

Combretum Micranthum Leaf Extract is a multi-functional botanical ingredient recognized for its potent soothing, protective, and hydrating properties. It actively strengthens the skin barrier, reduces inflammation, and offers robust antioxidant defense, making it suitable for a wide range of skin concerns. This extract contributes to overall skin health and resilience by addressing photo-oxidative stress and supporting cellular repair.

Summary

skin conditioning antioxidant anti-inflammatory moisturizer/humectant skin barrier strengthening skin elasticity restoration anti-aging post-sun repair DNA damage repair skin brightening spot fading anti-glycation skin detoxification

Science

Mechanism of Action

This extract functions as a comprehensive skin conditioning agent. It bolsters the skin barrier and significantly enhances hydration. Its anti-inflammatory action is evidenced by its ability to mitigate the production of pro-inflammatory cytokines, specifically IL-6 and IL-8, which are often exacerbated by UV exposure. Furthermore, it acts as a powerful antioxidant by inhibiting cellular reactive oxygen species (ROS) by 70.8% and nitrotyrosine by 56.9%, thereby safeguarding skin from photo-oxidative damage and mitigating signs of aging. The flavonoid content also supports post-sun repair, aids in UV-induced DNA damage repair, contributes to skin brightening and spot reduction, and offers anti-glycation and detoxification benefits.

Research

Clinical Evidence

High confidence
Effective range 0.1–5%
Optimal

2%

Key findings

  1. 01 Formulations containing this extract delivered optimal outcomes in restoring skin elasticity, enhancing environmental protection, strengthening the skin barrier, providing deep hydration, calming irritation in sensitive skin, and reducing visible signs of skin aging.
  2. 02 In a topical gel application, a 0.1% concentration effectively reduced sodium lauryl sulfate (SLS)-induced skin inflammation, leading to a 59.81% decrease in trans-epidermal water loss (TEWL) and a 22.4% reduction in skin redness (a* value) after 7 days.
  3. 03 In human epidermal primary keratinocytes, the extract increased cell survival by up to 39.6% against UV radiation irritation. It also significantly reduced UV-induced pro-inflammatory cytokines IL-6 and IL-8 by 57.6% and 42.5% respectively, while inhibiting cellular reactive oxygen species (ROS) by 70.8% and nitrotyrosine by 56.9%.

Transparency

Dusting Analysis

Not commonly dusted

There is no specific data within the provided research to indicate that Combretum Micranthum Leaf Extract is commonly 'dusted' at ineffective concentrations. Clinical efficacy has been observed at concentrations as low as 0.1% for anti-inflammatory effects and 2-5% for comprehensive benefits.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While oral toxicity studies in mice indicated no mortality at tested doses up to 2000 mg/kg, there is no dedicated Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) assessment specifically for its topical use in cosmetics. Slight, non-critical alterations in hepatic and renal biomarkers were observed in subacute oral studies without signs of systemic toxicity, suggesting a generally low risk for topical application based on its low irritancy profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Combretum Micranthum Leaf Extract is a valuable multi-active ingredient offering significant anti-inflammatory, antioxidant, hydrating, and barrier-strengthening benefits across all skin types.

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