Science
Mechanism of Action
This extract leverages a synergistic blend of bioactive compounds, including rosmarinic acid, caffeic acid, unique diterpenoids like coleousteroid A, and n-hexadecanoic acid. Rosmarinic acid, a polyphenol, delivers robust antioxidant and anti-inflammatory effects by neutralizing free radicals. Caffeic acid contributes mild antiviral and immune-modulating benefits. The diterpenoids gently inhibit phosphodiesterase-4 (PDE4), further contributing to its anti-inflammatory action. Additionally, n-hexadecanoic acid provides further antioxidant and anti-inflammatory support.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Topical oleoresin preparations applied twice daily for 2 weeks resulted in a 60% reduction in lesion size for minor eczema flare-ups.
Transparency
Dusting Analysis
No data available in research to suggest this ingredient is commonly 'dusted' in formulations.
The Formula
Formulation
Safety
Safety Profile
Coleus vettiveroides root extract has not undergone specific review by the CIR Expert Panel, SCCS, or FDA for cosmetic use. A rare skin rash has been reported in 1–2% of topical cream users. While oral acute toxicity studies in rats showed no significant toxic effects at high doses (up to 3200 mg/kg), this does not directly reflect topical safety. It is contraindicated during pregnancy and breastfeeding due to insufficient safety data, and caution is advised with blood thinners and hypotensive drugs due to mild antiplatelet and hypotensive effects.
Your Skin
Skin Compatibility
Our Assessment
Verdict
With promising anti-inflammatory and antioxidant benefits, *Coleus vettiveroides* root extract demonstrates valuable potential for calming sensitive and irritated skin, though comprehensive safety and efficacy studies are still emerging.
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