Science
Mechanism of Action
This extract functions by utilizing its rich array of flavonoids and phenolic compounds. These compounds act as chromophores, absorbing UV radiation to provide photoprotection and reduce sun-induced damage. It powerfully scavenges free radicals, mitigating oxidative stress. Additionally, it exhibits antimicrobial effects by disrupting bacterial cell walls, and anti-inflammatory action through the inhibition of COX-1 and COX-2 enzymes. For anti-aging and brightening, it inhibits key enzymes such as tyrosinase, collagenase, elastase, and hyaluronidase, addressing hyperpigmentation and preserving skin structure.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Highest sunscreen activity, yielding SPF 25.618±0.265 and PA 0.681±0.007 (star 3), was observed at 100 µg/mL in an ethanol extract. In vivo, a 1.5% cream formulation significantly reduced erythema after sun exposure.
- 02 Significant skin-lightening activity was demonstrated through tyrosinase inhibition with an IC50 of 39.059 µg/mL (ethanol extract).
- 03 Anti-aging benefits include antioxidant activity (IC50 79.734 µg/mL), collagenase inhibition (IC50 76.838 µg/mL), elastase inhibition (IC50 143.384 µg/mL), and hyaluronidase inhibition (IC50 122.467 µg/mL), observed with ethanol and ethyl acetate extracts.
- 04 Moderate antioxidant activity was measured with a DPPH radical scavenging IC50 of 70.06 µg/mL, while a water extract showed weaker activity with an IC50 of 244.42 µg/mL.
- 05 Exhibited antibacterial effects against Gram-positive aerobes (MIC 1.56-12.50 mg/mL, MBC 3.13-12.50 mg/mL) and Gram-negative obligate anaerobes (MIC 3.13-12.50 mg/mL, MBC 6.25-200.00 mg/mL) relevant to peri-implantitis.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Ethanolic extracts demonstrate robust stability for its sunscreen, skin lightening, and anti-aging properties. However, some instability has been observed in film-coated tablets at room temperature for anti-inflammatory applications. The final SPF value of gel formulations is also notably influenced by the choice of gelling agents.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not reviewed this ingredient. While FDA's Voluntary Cosmetics Reporting Program shows 'No Reported Uses', in vitro studies indicate no cytotoxicity on human gingival fibroblast cells at tested concentrations, and no significant hemolysis (safe below 5%) was observed even at 100 µg/mL. Paula's Choice notes it is generally non-irritating, though potential irritation could arise from problematic ingredient combinations or formulation issues.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Coleus Scutellarioides Leaf/Stem Extract is a valuable botanical active offering extensive benefits including photoprotection, antioxidant defense, anti-aging, skin brightening, and antimicrobial properties, supported by both in vitro and in vivo data.
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References
Sources