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Moumoujus

COIX LACRYMA-JOBI MA-YUEN SEED.

Valuable CAS - / SKIN CONDITIONING

Coix Lacryma-Jobi Ma-Yuen Seed Extract, derived from Job's Tears, is a multi-functional ingredient revered for its comprehensive skin benefits. Rich in vitamins, minerals, and antioxidants, it actively promotes skin hydration, calms inflammation, and supports natural cell regeneration. This extract is exceptionally well-suited for all skin types, addressing a spectrum of concerns from dryness and sensitivity to hyperpigmentation and excess sebum.

Summary

Antioxidant Skin-Conditioning Anti-inflammatory Humectant Skin brightening Exfoliant Sebum control

Science

Mechanism of Action

This botanical extract operates through multiple pathways to enhance skin health. It significantly reduces inflammation by inhibiting pro-inflammatory mediators such as IL-1α, PGE2, and COX-2 upregulation, thereby preventing inflammation-mediated dryness. Its anti-pruritic and immunomodulatory effects stem from inhibiting tryptase expression, histamine release, and reducing IL-31 expression. Rich in antioxidants like phenols and flavonoids, along with key nutrients including thiamine, riboflavin, niacin, ascorbic acid, ferulic acid, caffeic acid, and ceramides, it actively protects the skin from environmental stressors and free radical damage. Furthermore, it aids in skin brightening by curbing tyrosinase activity, a key enzyme in melanin production, showing 48.4% inhibition on B16F10 melanocytes and 50.7% on human tyrosinase fragments in specific concentrations. Its moisturizing properties enhance deep epidermal hydration, while gentle exfoliating actions help remove dead skin cells and control sebum, leading to improved texture and balanced skin pH.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated prevention of sodium dodecyl sulfate (SDS)-induced inflammation-mediated skin dryness in HR-1 hairless mice by suppressing pro-inflammatory mediators (IL-1α, PGE2, COX-2 upregulation).
  2. 02 Achieved significant inhibition of nitric oxide (NO) production in HMC-1 cells, with concentrations up to 100 μg/mL showing no cytotoxicity (over 100% cell viability).
  3. 03 Resulted in 48.4% inhibition of tyrosinase activity in B16F10 melanocytes and 50.7% on human tyrosinase (hTyr) fragment 369–377, indicating skin brightening potential.

Transparency

Dusting Analysis

Not commonly dusted

Optimal usage levels for Coix Lacryma-Jobi Ma-Yuen Seed in cosmetic formulations have not been firmly established, which can lead to variability in efficacy across products, though there is no evidence of intentional dusting.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract is described as having a 'low pH,' suggesting it may be well-suited for formulations targeting skin pH balance or requiring acidic conditions for stability or efficacy. It contains both water-soluble (polyphenolics) and oil-soluble components (e.g., coixenolide, lipids).

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Coix Lacryma-Jobi Ma-Yuen Seed is recognized by the FDA's Global Substance Registration System (UNII: 8DW238I7ZI) and considered safe for cosmetic use by regulatory authorities such as the European Union. While generally possessing a good safety profile, individuals with sensitive skin may experience mild irritation or redness; a sensitivity patch test is advisable prior to widespread use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Coix Lacryma-Jobi Ma-Yuen Seed is a valuable, multi-beneficial ingredient suitable for all skin types, offering significant anti-inflammatory, brightening, hydrating, and protective properties through well-documented mechanisms, despite the absence of firmly established optimal cosmetic usage levels.

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