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COCOYL PENTAPEPTIDE-9.

Valuable

An advanced lipid-conjugated messenger peptide designed to optimize cellular communication and structural protein synthesis. By combining a fatty acid chain with a specific five-amino acid sequence, this biomimetic ingredient enhances skin penetration to target the deeper dermal layers for visible rejuvenation.

Cell-communicating Skin-restoring Collagen-boosting

Science

This ingredient functions as a cell-signaling agent that mimics natural biological processes to stimulate the production of the extracellular matrix. It primarily targets collagen synthesis and strengthens the dermal-epidermal junction, facilitating faster tissue repair and improving the skin's overall structural architecture to combat sagging and fine lines.


Research

Low confidence
Effective range N/A
Optimal

0.002%

Key findings

  1. 01 While specific data for the Cocoyl-9 variant is emerging, studies on structural analogs like Cyclized Hexapeptide-9 at 0.002% demonstrated a measurable reduction in wrinkle area and roughness over a 56-day period, showing performance metrics that rivaled traditional retinol.

Transparency

Commonly dusted
Min. effective
0.0005%
Red flag below
0.0001%

Peptides are exceptionally potent at micro-doses, which often leads manufacturers to include them at negligible levels—frequently below 0.0001%—purely for marketing claims rather than physiological effect.


The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

The cocoyl attachment suggests improved lipophilicity compared to standard peptides; however, like most peptides, it should be protected from extreme pH environments to prevent hydrolysis.

Synergies

  • Hyaluronic Acid
  • Ceramides
  • Other Signal Peptides

Safety

CIR Status
Safe as used
Pregnancy
Safe
Sensitization risk Low

Categorized as an amino acid alkyl amide, the CIR Expert Panel deems this class of ingredients safe for cosmetic use when formulated to be non-irritating.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A sophisticated signaling peptide with high potential for structural skin repair, though more direct clinical trials are required to fully validate its efficacy versus established benchmarks.


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