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COCAMIDOPROPYLAMINE OXIDE.

Valuable CAS 68155-09-9 / CLEANSING, HAIR CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - FOAM BOOSTING, SURFACTANT - HYDROTROPE

Cocamidopropylamine Oxide is a versatile amphoteric surfactant and conditioning agent. It effectively cleanses skin and hair by emulsifying oils and dirt, simultaneously enhancing formula mildness and boosting foam.

Summary

Cleansing Foam Boosting Hair Conditioning Hydrotrope Surfactant

Science

Mechanism of Action

This ingredient functions primarily as a surfactant, effectively reducing the surface tension within formulations. It acts as a cleansing agent by readily mixing with and suspending oil and dirt, allowing them to be easily rinsed away. Beyond cleansing, it provides conditioning benefits to both skin and hair and contributes to enhanced foam generation.

Research

Clinical Evidence

High confidence
Effective range 0.07–4%
Optimal

4%

Key findings

  1. 01 Demonstrated not to be a sensitizer, although some reactions indicative of mild irritation were observed in a clinical study.
  2. 02 No evidence of dermal sensitization was found in two repeat-insult patch tests utilizing a facial wash product.
  3. 03 Evaluated as not being a primary dermal irritant.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
4%
Red flag below
4%

While generally well-tolerated at recommended levels, concentrations exceeding 4.0% of Cocamidopropylamine Oxide have been identified as potentially leading to allergic reactions and irritation on the skin and scalp. Precision in formulation is key to avoid these adverse effects.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

Cocamidopropylamine Oxide exhibits excellent stability and good compatibility across both acid and alkaline mediums, remaining unaffected by acid and hard water. It also demonstrates stability in the presence of sodium hypochlorite. Prolonged heating above 100°C should be avoided to maintain its integrity.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
4%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has determined Cocamidopropylamine Oxide to be safe when used in rinse-off cosmetic products, with typical concentrations reported between 0.07% and 4.0%. For leave-on applications, existing data were considered insufficient, indicating a need for further dermal penetration studies. It demonstrates low toxicity in animal and in vitro tests, and current genotoxicity data suggest no carcinogenic potential. The CIR Panel noted the absence of reproductive and developmental toxicity data. Use at concentrations above 4.0% may elevate the risk of skin and scalp irritation or allergic reactions.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Cocamidopropylamine Oxide is a valuable ingredient, particularly in rinse-off formulations up to 4.0%, offering efficient cleansing, conditioning, and foam-boosting properties with low inherent irritancy and comedogenicity.

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