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CNIDIUM OFFICINALE ROOT EXTRACT.

Valuable CAS 168456-52-8 / SKIN CONDITIONING

Cnidium Officinale Root Extract is a multi-functional botanical ingredient known for its soothing, antibacterial, and antioxidant properties. It contributes to a strengthened skin barrier, improved hydration, and balanced skin tone, making it suitable for a wide range of skin concerns.

Summary

Antioxidant Soothing Anti-acne Skin-conditioning

Science

Mechanism of Action

This extract operates through multiple pathways to enhance skin health. It functions as a potent antioxidant, actively decreasing DPPH free radicals, and delivers soothing benefits by suppressing inflammation-associated molecules. Specific actions include inhibiting nitric oxide (NO) release and downregulating inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression, key mediators of inflammation. Furthermore, it stimulates microcirculation, provides antibacterial support, helps regulate sebum production, and can influence melanin synthesis pathways by affecting proteins like MITF, tyrosinase, TRP1, and TRP2, contributing to improved skin tone and clarity.

Research

Clinical Evidence

High confidence
Effective range 0.01–5%
Optimal

1%

Key findings

  1. 01 Demonstrated significant antifungal efficacy against Candida albicans, producing inhibition zones of 20 ± 1.8 mm and 23.6 ± 1.6 mm, respectively.
  2. 02 Exhibited antibacterial activity (MIC) against various bacteria, including P. acnes, a key contributor to acne vulgaris.
  3. 03 Systemic exposure from leave-on cosmetic products was estimated to be below Threshold of Toxicological Concern (TTC) thresholds for all components, supporting its safety at this concentration.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Cnidium Officinale Root Extract maintains stability under standard storage conditions. It is generally neutral to slightly acidic, which ensures broad compatibility across diverse cosmetic formulations. Protection from excessive heat and direct light is recommended to preserve its integrity.

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
1%
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel has not specifically assessed Cnidium Officinale Root Extract, a safety evaluation using the Threshold of Toxicological Concern (TTC) approach suggests that systemic exposure from leave-on cosmetic products containing up to 1% concentration is below established safety thresholds. This indicates a generally favorable safety profile in cosmetic applications. Isolated instances of skin irritation have been reported, typically linked to individual sensitivities.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Cnidium Officinale Root Extract is a valuable ingredient offering a robust array of benefits including antibacterial, antioxidant, and soothing properties, suitable for all skin types within a well-established safety range.

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