Science
Mechanism of Action
The extract operates through a multi-pathway approach to dermal preservation: it neutralizes Reactive Oxygen Species (ROS) while simultaneously inhibiting elastase and MMP-1 enzymes which break down elastin and collagen. Furthermore, it actively stimulates the synthesis of procollagen, the essential precursor to the skin's structural support network.
Research
Clinical Evidence
Medium confidence0.01%
Key findings
- 01 Concentrations of 10 ppm Clitocybin A demonstrated a 112.9% increase in procollagen synthesis in human dermal fibroblasts.
- 02 Elastase activity was reduced by up to 8.31% at a 10 ppm concentration, indicating significant anti-wrinkle potential.
- 03 At 100 µg/ml, the extract exhibited a 33.1% inhibition of MMP-1, the enzyme responsible for collagen breakdown following UV exposure.
Transparency
Dusting Analysis
Because this extract is biologically active at parts-per-million (ppm) levels, it is frequently used in 'marketing doses' that fall below the 1-10 ppm threshold required to trigger significant procollagen synthesis.
The Formula
Formulation
Stability
Highly stable across a broad pH range (5.0–10.0), making it versatile for various cosmetic delivery systems.
Synergies
- Vitamin C
- Peptides
- Retinoids
Safety
Safety Profile
In-vitro testing on HDF-N cells shows no significant cytotoxicity at concentrations up to 10 ppm, with cell viability maintained above 94%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated biotechnological ingredient that provides targeted structural support and potent antioxidant defense for aging or photo-damaged skin.
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References
Sources