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Moumoujus

CLEMATIS MANSHURICA EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Clematis Manshurica Extract is a botanical active renowned for its multifaceted dermatological benefits. This extract demonstrates potent anti-inflammatory, antioxidant, and skin brightening properties, alongside a unique capacity to protect cellular integrity, making it valuable for comprehensive skin support.

Summary

Antioxidant Anti-inflammatory Skin Brightening Skin Conditioning Anti-apoptotic

Science

Mechanism of Action

Clematis Manshurica Extract acts through several sophisticated pathways to enhance skin health. Rich in active compounds such as triterpene saponins, clematosides, hederagenin, and anemonol, its preparations effectively modulate inflammatory responses by significantly reducing the production of pro-inflammatory mediators, including nitric oxide (NO), prostaglandin E2 (PGE2), and cytokines like TNF-α, IL-1β, and IL-6. Beyond inflammation, it offers skin brightening by inhibiting melanin synthesis and tyrosinase expression. Furthermore, this extract exhibits protective effects against cellular apoptosis by maintaining crucial antiapoptotic proteins like Bcl-xL, Bcl-2, and 14-3-3.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.1%
Optimal

N/A

Key findings

  1. 01 An ethanolic extract significantly blocked pro-inflammatory mediators nitric oxide (NO) by up to 77% and prostaglandin E2 (PGE2) by up to 59% in stimulated mouse peritoneal macrophages. It also inhibited cell proliferation and cytokine production (IL-2, IFN-gamma) in stimulated splenocytes.
  2. 02 Clematis mandshurica Ruprecht root extract (CRE) inhibited protein expression of LPS-induced iNOS, COX-2, NF-κB, and MAPKs, along with the production of TNF-α, IL-1β, IL-6, NO, and PGE2 in RAW 264.7 macrophage cells. It also demonstrated an anti-edema effect in a carrageenan-induced rat hind paw edema model.
  3. 03 A purified extract prevented staurosporin-induced downregulation of antiapoptotic bcl-2 family proteins (Bcl-xL, Bcl-2) and premitochondrial antiapoptotic protein 14-3-3, thereby preventing apoptosis in rat chondrocytes.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Ethanolic extracts are commonly utilized, indicating solubility in polar organic solvents and likely water. No specific optimal pH range for stability was identified.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific CIR, SCCS, or FDA safety status exists for Clematis Manshurica Extract in cosmetics. While historical reports for crude Clematis species suggest potential irritancy or toxicity when undiluted, these refer to raw plant material or other species, not necessarily a cosmetic extract at typical concentrations. The safety profile for cosmetic use remains largely undefined, with 'no data available' being the current assessment for the extract.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Clematis Manshurica Extract demonstrates strong in vitro and animal evidence for anti-inflammatory, antioxidant, and anti-apoptotic benefits at low concentrations, indicating valuable potential for skin health, though further human cosmetic safety and efficacy data is warranted.

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