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Moumoujus

CITRUS SUDACHI PEEL EXTRACT.

Valuable / ANTIMICROBIAL, ANTIOXIDANT

Citrus Sudachi Peel Extract is a botanical ingredient derived from the Sudachi fruit, primarily recognized for its ability to precisely modulate keratinocyte behavior. It effectively suppresses excessive cell proliferation and promotes healthy differentiation, offering targeted benefits for skin conditions characterized by cellular overgrowth, while also providing antioxidant and antimicrobial properties.

Summary

Antimicrobial Antioxidant Skin-conditioning Antiproliferative Pro-differentiation

Science

Mechanism of Action

This extract operates by inhibiting the epidermal growth factor receptor (EGFR)-extracellular regulated kinase (ERK) signaling pathway. Specifically, it blocks EGF-induced EGFR activation and TNF-α-induced ERK 1/2 activation in keratinocytes, thereby suppressing their proliferation. Concurrently, it supports healthy skin by potentiating calcium-induced keratinocyte differentiation. The peel's richness in phenolic compounds, including sudachitin, hesperidin, naringin, and narirutin, also contributes to its observed antioxidant and antimicrobial activities.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

A toxicological evaluation of Citrus sudachi Extract Powder reported an acute oral LD50 greater than 5000 mg/kg body weight and an acute dermal LD50 greater than 2000 mg/kg body weight in rats. It was classified as 'slightly irritating' to the skin with a Primary Dermal Irritation Index (PDII) of 0.8, and 'minimally irritating' to the eye with a maximum mean total score (MMTS) of 2.7. No mutagenicity was observed in Ames' bacterial reverse mutation assay or in vitro mammalian cell gene mutation tests. The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed Citrus Sudachi Peel Extract; however, general CIR guidelines for citrus-derived peel ingredients recommend that leave-on products do not exceed 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP) to ensure safety.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Citrus Sudachi Peel Extract is a valuable ingredient, demonstrating precise mechanistic action in suppressing keratinocyte hyperproliferation and promoting differentiation, coupled with antioxidant and antimicrobial properties, making it beneficial for specific skin concerns.

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