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Moumoujus

CITRUS SUDACHI FRUIT EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING

Derived from the Japanese sudachi citrus, Citrus Sudachi Fruit Extract is a dynamic botanical ingredient. It precisely modulates skin cell behavior, offering robust antioxidant benefits and supporting overall skin health through its unique polyphenol profile.

Summary

Antioxidant Skin-conditioning Humectant Anti-inflammatory Antimicrobial Keratinocyte Proliferation Suppressant Keratinocyte Differentiation Promoter

Science

Mechanism of Action

This extract precisely influences skin cellular activity by inhibiting epidermal growth factor (EGF)-induced EGF receptor (EGFR) activation and tumor necrosis factor (TNF)-α-induced extracellular regulated kinase (ERK) 1/2 activation. This action effectively suppresses keratinocyte proliferation while promoting their differentiation. Its key polyphenol, sudachitin, provides significant antioxidant, antimicrobial, and anti-inflammatory effects by inhibiting nitric oxide production and modulating matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) expression.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

3%

Key findings

  1. 01 In in-vitro studies, 3% Sudachi Peel Extract significantly suppressed cell proliferation in both immortalized human keratinocyte cell lines (HaCaT) and primary normal human epidermal keratinocytes, without inducing cytotoxicity. It also enhanced calcium-induced keratinocyte differentiation, indicating potential benefits for skin conditions characterized by hyperproliferative epidermal keratinocytes.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated citrus fruit-derived ingredients, deeming them safe for use in cosmetic products when formulated to be non-sensitizing and non-irritating. For leave-on products, the content of 5-methoxypsoralen (5-MOP) must not exceed 0.0015% (15 ppm). While generally recognized as safe (GRAS) by the FDA, a safety evaluation of a novel Citrus sudachi Extract Powder indicated it was 'slightly irritating to the skin' with a Primary Dermal Irritation Index (PDII) of 0.8 in a rabbit study, and 'minimally irritating to the eye' with a Maximum Mean Total Score (MMTS) of 2.7. No mutagenicity was observed in standard assays. Acute oral LD50 was >5000 mg/kg body weight, and acute dermal LD50 was >2000 mg/kg body weight.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Citrus Sudachi Fruit Extract is a valuable, multifunctional ingredient that precisely regulates keratinocyte proliferation and differentiation, delivers potent antioxidant benefits, and offers broad skin-conditioning properties with a low risk of irritation when properly formulated.

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