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CITRUS SPHAEROCARPA PEEL OIL.

Avoid / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Citrus Sphaerocarpa Peel Oil, derived from the peel of the Citrus sphaerocarpa fruit, is a botanical extract recognized for its complex composition of monoterpenes, phenolic compounds, and flavonoids. This ingredient primarily offers antioxidant benefits and contributes a natural fragrance.

Summary

Masking Perfuming Skin conditioning Acne treatment potential

Science

Mechanism of Action

The mechanism of Citrus Sphaerocarpa Peel Oil's action is rooted in its rich phytochemical profile. Its antioxidant properties are largely attributed to major components such as limonene, myrcene, γ-terpinene, terpinolene, and β-pinene, alongside various phenolic compounds and flavonoids, which scavenge free radicals. Limonene also exhibits antibacterial effects, while coumarins and furanocoumarins may contribute to antifungal activity. These combined actions suggest a potential for treating skin acne by addressing oxidative stress and microbial factors.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Strong antioxidant activity (IC₅₀ of 8.13 µg/ml) demonstrated via DPPH assay.
  2. 02 In vitro cytotoxicity against MCF-7 (human breast cancer) cell lines.
  3. 03 In vitro cytotoxicity against HeLa (human cervical cancer) cell lines.

Transparency

Dusting Analysis

Not commonly dusted

The primary concern with Citrus Sphaerocarpa Peel Oil lies in strictly adhering to safety limits rather than insufficient concentration for efficacy, making dusting a non-issue.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As an essential oil, it is inherently hydrophobic and oil-soluble. While some oxygenated components may exhibit minor water solubility, the overall oil is best incorporated into oil-based formulations. Thermal compatibility with other ingredients is essential during manufacturing and storage to preserve its integrity and prevent undesirable reactions.

Conflicts

  • Concentrations of 5-methoxypsoralen (5-MOP) exceeding 0.0015% (15 ppm) in leave-on products.
  • High levels of sensitizing constituents such as limonene, citral, and other monoterpenes.
  • Presence of pesticide residues and heavy metals, necessitating stringent quality control and good manufacturing practices.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.0015%
Sensitization risk Moderate

The CIR Expert Panel considers citrus-derived peel oils safe under specific formulation conditions, requiring products to be non-sensitizing and non-irritating. For leave-on applications, the concentration of 5-methoxypsoralen (5-MOP) must not exceed 0.0015% (15 ppm). Specific constituents like limonene, citral, monoterpenes, and furocoumarins are identified as potential sensitizers, mandating careful control of their levels in finished formulations.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to a very low maximum concentration limit for leave-on products (0.0015% for 5-MOP), a medium irritancy potential, and the presence of known sensitizers, this ingredient carries significant formulation challenges and risks, making it generally not recommended for precision skincare.

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