Science
Mechanism of Action
This ingredient operates through its diverse phytochemical composition, including flavonoids, alkaloids, terpenoids, and phenols. It demonstrates potent antioxidant action by efficiently scavenging nitric oxide (NO) in human keratinocytes and fibroblasts, reducing oxidative stress. Furthermore, it exhibits anti-inflammatory effects and has shown antifungal efficacy against fungi like Pityrosporum ovale, suggesting a broad spectrum of dermal activity.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Exhibited nitric oxide (NO) scavenging capacity at 4.46 mg/mL (IC50) in human keratinocytes and fibroblasts during an in vitro antioxidant study.
- 02 Demonstrated antifungal effectiveness against Pityrosporum ovale, with the highest inhibition zone diameter (16.20 mm) observed at a 75% concentration in a laboratory experiment. Effectiveness was also noted at 25% and 50%.
- 03 A kaffir lime leaf extract (distinct but related to leaf water) showed 50% inhibition of xanthine oxidase enzyme activity (IC50: 285.82 ppm) in an in vitro study, suggesting anti-inflammatory potential.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While specific cosmetic formulation stability data is limited, the kaffir lime tree thrives in a slightly acidic pH range of 5.5-6.5, which may indicate optimal stability for the ingredient's aqueous components within this range.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed 'Citrus Hystrix Leaf Water.' While 'Citrus Hystrix Leaf Oil' was included in a use survey, no data was reported. A general CIR report on citrus flower- and leaf-derived ingredients suggests safety when formulated to be non-irritating and non-sensitizing. The FDA generally recognizes some Citrus flowers and leaves as GRAS for food, but this doesn't directly address this specific ingredient in cosmetics.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Citrus Hystrix Leaf Water is a valuable ingredient, offering antioxidant, anti-inflammatory, and antifungal properties with low irritancy, though comprehensive cosmetic safety review data specific to 'Leaf Water' is currently insufficient.
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