Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

CITRULLINE.

Valuable CAS 372-75-8 / SKIN CONDITIONING

Citrulline is a non-essential amino acid, naturally occurring in the body and certain plant sources, recognized for its diverse benefits in dermatological applications. It functions as a potent antioxidant, enhances cellular vitality, and supports the skin's inherent repair and hydration mechanisms.

Summary

Skin conditioning Humectant Antioxidant Supports wound healing Anti-aging Enhances skin hydration Promotes skin repair Supports skin brightening

Science

Mechanism of Action

Citrulline primarily acts by promoting the synthesis of nitric oxide (NO) in the skin, which in turn improves localized blood flow and nutrient delivery. This enhanced microcirculation supports efficient collagen production and accelerated skin cell turnover, leading to improvements in elasticity and hydration. Furthermore, its robust antioxidant capacity scavenges damaging hydroxyl radicals and aids in the regeneration of arginine, further supporting NO synthesis. These combined actions contribute to wrinkle prevention, enhanced skin brightness, improved hydration, and support wound healing through accelerated fibroblast proliferation and angiogenesis.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data suggests that Citrulline is prone to 'dusting' or typically requires specific considerations regarding dusting thresholds in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Citrulline is freely soluble in water (200 g/L at 20 °C) and is characterized by high thermal stability, with decomposition initiated above 213 °C. It is non-hygroscopic and generally stable under physiological conditions, with a pKa of 2.43.

Synergies

  • Arginine (for enhanced nitric oxide synthesis)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Citrulline, a naturally occurring amino acid, is widely recognized as safe for oral consumption. For topical applications, it demonstrates a low potential for skin, eye, or lung irritation. It is not listed on EWG's restricted or unacceptable lists, and no specific maximum concentration for cosmetic use has been established by CIR, SCCS, or FDA in the available literature.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Citrulline is a valuable ingredient for precision skincare, leveraging its multifaceted role in nitric oxide production and robust antioxidant properties to effectively enhance skin hydration, support repair mechanisms, and address visible signs of aging with a favorable safety and compatibility profile.

Related

Similar Ingredients

Finding similar ingredients…