Science
Mechanism of Action
This extract functions via a multi-targeted approach: it inhibits the expression of pro-inflammatory cytokines IL-1β and IL-6 while neutralizing free radicals to prevent lipid peroxidation. It enhances cellular vitality by boosting ATP synthesis and protects DNA from the cumulative damage caused by UVB and High-Energy Visible (blue) light, while simultaneously supporting epidermal differentiation for a reinforced barrier.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 In-vitro analysis demonstrated significant anti-inflammatory activity at concentrations as low as 1.56 µg/mL, reducing mRNA gene expression of key inflammatory markers.
- 02 Comparative studies indicate higher radical scavenging capacity and lipid peroxidation inhibition than its relative, Cistus incanus.
- 03 Genotoxicity testing confirmed no mutagenic potential at concentrations up to 200 µg/mL, with lower doses showing protective antigenotoxic effects.
Transparency
Dusting Analysis
Often utilized at trace amounts for its 'masking' properties or botanical storytelling, Cistus Monspeliensis requires precise inclusion levels (typically above 0.5% in commercial extracts) to deliver its documented photoprotective and anti-inflammatory benefits.
The Formula
Formulation
Stability
Maintain in a cool, dark environment to preserve the integrity of the heat-sensitive polyphenolic compounds.
Synergies
- UV filters
- L-Ascorbic Acid
- Niacinamide
- Hyaluronic Acid
Safety
Safety Profile
Rated as low concern by EWG. While in-vitro cytotoxicity was noted at high microgram levels (above 50 µg/mL), these concentrations are significantly higher than what is typically achieved through topical epidermal absorption.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance botanical active essential for modern urban defense, providing scientifically backed protection against environmental and digital stressors.
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References
Sources