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Moumoujus

CISTUS LADANIFERUS RESIN.

Valuable CAS 8016-26-0 / 84775-64-4 / FRAGRANCE

Cistus Ladaniferus Resin, also known as Labdanum resin, is a botanical extract sourced from the Mediterranean Rockrose plant. Rich in terpenoid and flavonoid compounds, this ingredient offers a spectrum of benefits for comprehensive skincare, including anti-aging, anti-inflammatory, and protective properties.

Summary

Anti-aging Anti-inflammatory Antioxidant Antimicrobial UV Absorber (potential) Masking

Science

Mechanism of Action

The efficacy of Cistus Ladaniferus Resin is rooted in its diverse profile of active compounds, notably labdane-type diterpenes and methylated flavonoids. Its antioxidant activity involves effectively scavenging Reactive Oxygen Species (ROS), thereby shielding the skin from oxidative stress and photoaging. Anti-inflammatory effects are primarily mediated by flavonoid aglycones, which inhibit the release of nitric oxide in inflammatory cells. Furthermore, its anti-aging potential stems from inhibiting elastase, an enzyme that degrades elastin, thus helping to preserve skin elasticity and reduce wrinkle formation. Flavonoids within the resin also contribute to UV protection by absorbing UVA radiation, and it demonstrates targeted antimicrobial activity against specific bacteria like Staphylococcus aureus.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 At an in vitro concentration of 1 mg/mL, labdanum absolute demonstrated a 22% inhibition of elastase activity, suggesting its potential to support skin's structural integrity and mitigate signs of aging.
  2. 02 Flavonoid fractions, at 15 µg/mL, potently inhibited nitric oxide production in LPS-induced RAW 264.7 cells by 84-98%, underscoring significant anti-inflammatory capabilities.
  3. 03 The resin exhibited antimicrobial efficacy against Staphylococcus aureus, with Minimum Inhibitory Concentrations (MIC) of 1.2 mg/mL for the absolute and less than 0.3 mg/mL for its fractions.
  4. 04 Spectrophotometric analysis revealed a Sun Protection Factor (SPF) of approximately 5 for labdanum absolute, which increased to SPF 13 for its flavonoid fractions, indicating potential natural UV protection.
  5. 05 Its essential oil, at 10 µL/mL, showed robust antibacterial activity against several common pathogens including Staphylococcus aureus and Escherichia coli, along with antifungal action against C. tropicalis and C. neoformans.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The resin demonstrates stability across a broad pH range (from pH 2 to 11) during typical extraction processes involving alkaline and acidic conditions. Optimal processing often occurs at temperatures around 60°C to preserve phytochemical integrity.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
10%
Sensitization risk Moderate

While the FDA permits 'LABDANUM, ABSOLUTE (CISTUS SPP.)' as a direct food additive and ECHA registers it for cosmetic use reporting 'no physical, environmental, and human health hazards', specific hazard statements include H315 (Causes skin irritation), H317 (May cause an allergic skin reaction), and H320 (Causes eye irritation). Further toxicological and skin irritation tests for cosmetic applications are advised. The IFRA Code of Practice recommends usage levels up to 10.0000% in fragrance concentrate. The oral-rat LD50 is 8980 mg/kg.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Cistus Ladaniferus Resin offers valuable anti-aging, anti-inflammatory, and antimicrobial properties, making it a promising ingredient for comprehensive skincare, though caution is advised due to its moderate irritation potential.

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