Science
Mechanism of Action
This extract functions as a comprehensive skin protectant and conditioner. Its antioxidant capacity involves scavenging free radicals, thereby mitigating oxidative stress that contributes to skin aging and damage. Anti-inflammatory actions are observed through the reduction of inflammatory responses and the inhibition of pro-inflammatory mediators such as nitric oxide. The extract also contributes to skin health by exhibiting antimicrobial activity against various microorganisms. Furthermore, its flavonoid content provides demonstrable UV-protective qualities, while anti-elastase activity helps maintain skin elasticity and firmness, countering age-related degradation. As a humectant, it aids in retaining skin moisture, and generally acts as a skin conditioning agent.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Demonstrated significant antioxidant effects, with IC50 values ranging from 4.08 to 266.6 μg/mL across various extracts.
- 02 In vivo studies showed a reduction in paw edema inflammation by 66.67% to 77.78% at doses of 150-200 mg/kg b.m. (aqueous extract). In vitro, it inhibited nitric oxide production by 84% to 98% at 15 µg/mL (flavonoid fraction being most active).
- 03 Exhibited a spectrophotometric Sun Protection Factor (SPF) of 13 at a concentration of 100 µg/mL (flavonoid fraction).
- 04 Inhibited elastase activity by 13% to 22% at a concentration of 1 mg/mL (absolute and flavonoid extracts), suggesting a role in preserving skin elasticity.
- 05 Demonstrated antimicrobial activity against Staphylococcus aureus, with Minimum Inhibitory Concentration (MIC) values of 1.2 mg/mL for labdanum absolute and <0.3 mg/mL for certain fractions.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
ECHA registrations for labdanum resin, which is derived from Cistus ladanifer, indicate no physical, environmental, or human health hazards, supported by a full toxicological assessment. EWG Skin Deep rates Cistus Ladaniferus Leaf/Stem Water with 'LOW' concern across multiple hazard categories, including cancer, allergies & immunotoxicity, and developmental/reproductive toxicity. Acute and sub-chronic toxicity studies in animal models showed no mortality or adverse effects at doses up to 2000 mg/kg, and minimal toxicity was observed against human skin-derived fibroblast cells for various extracts.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cistus Ladaniferus Leaf/Stem Water Extract is a valuable, multi-beneficial ingredient offering proven antioxidant, anti-inflammatory, UV-protective, and anti-aging properties, making it suitable for a wide range of precision skincare applications.
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References
Sources