Science
Mechanism of Action
This extract functions primarily through its rich content of polyphenolic compounds, including flavonoids and phenolic acids. These components exert potent antioxidant activity by efficiently scavenging free radicals and inhibiting lipid peroxidation, thereby safeguarding skin cells from oxidative stress, a primary contributor to premature aging and damage. It also demonstrates significant anti-inflammatory capabilities by modulating inflammatory mediators, specifically through the strong inhibition of nitric oxide production. Furthermore, the extract provides natural UV protection, largely attributed to its flavonoid content, which absorbs UVA radiation. Its anti-aging efficacy is supported by the inhibition of elastase, an enzyme responsible for degrading skin elasticity. Lastly, its antimicrobial properties help in controlling various skin microorganisms, contributing to a balanced skin microbiome, while acting as a skin conditioning agent.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Exhibited significant antioxidant effect with an IC50 of 266.6 ± 0.828 μg/mL via DPPH assay, and a notable reducing power of 0.494 ± 0.035 via FRAP test.
- 02 Demonstrated natural sun protecting activity, providing an SPF value between 3.42 and 3.77.
- 03 Inhibited nitric oxide production in LPS-induced RAW 264.7 cells by 84% to 98%, indicating high anti-inflammatory potential.
- 04 Showed anti-elastase activity, inhibiting the enzyme by 22% for the absolute extract and 13% for the flavonoid extract, suggesting support for skin elasticity.
- 05 Demonstrated antimicrobial activity against Staphylococcus aureus with a Minimum Inhibitory Concentration (MIC) of 1.2 mg/mL for the absolute extract, and less than 0.3 mg/mL for certain fractions.
Transparency
Dusting Analysis
There is no information within the provided research data to suggest that this ingredient is commonly 'dusted' or used at ineffective percentages in formulations.
The Formula
Formulation
Stability
Specific optimal pH range and stability notes were not provided in the research data.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) and SCCS have not specifically reviewed this ingredient. However, ECHA registrations for labdanum resin derived from Cistus ladaniferus indicate no reported physical, environmental, or human health hazards. INCI Beauty also reports 'No penalty' across all safety categories. Studies generally show minimal toxicity against human skin-derived fibroblast cells. Preliminary animal tests on an aqueous leaf extract showed an LD50 of 831.76 ± 0.12 mg/kg in mice with 0% mortality up to 400 mg/kg over 14 days, suggesting a moderate to low toxicity profile at relevant exposure levels.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cistus Ladaniferus Leaf/Stem Extract is a valuable active ingredient, demonstrating robust antioxidant, anti-inflammatory, anti-aging, UV protective, and antimicrobial properties, making it a comprehensive asset for diverse skincare formulations.
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