Science
Mechanism of Action
Cissampelos Pareira Root Extract, particularly its pectin component, exerts antioxidant activity by effectively mitigating hydrogen peroxide-induced oxidative damage. Beyond this protective action, it significantly contributes to enhancing both skin hydration and elasticity. Phytochemical analyses reveal a diverse composition, including terpenoids, alkaloids, tannins, amino acid proteins, and carbohydrates, with crude extracts also exhibiting anti-inflammatory and antimicrobial properties.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 An 8-week clinical trial involving human volunteers utilizing serum formulations containing pectin from Cissampelos pareira (PCP) at concentrations of 0.5% w/w and 1.0% w/w demonstrated significant improvements in skin hydration and elasticity. The study also noted improvements in skin smoothness, scaliness, and the appearance of wrinkles, though these were not statistically significant.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Pectin solutions derived from Cissampelos pareira typically exhibit an acidic pH, with a 1.0% w/v solution measured at 3.74 ± 0.04. Stability assessments indicate that the pectin maintains its physical appearance and total polysaccharide content consistently after various heating–cooling cycles, suggesting good thermal stability.
Safety
Safety Profile
While comprehensive toxicological research is still recommended for Cissampelos pareira, formulations containing its pectin component have shown no cytotoxicity at 1 mg/mL. Furthermore, an 8-week clinical trial on human volunteers reported no instances of skin irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cissampelos Pareira Root Extract is a valuable ingredient, clinically proven to enhance skin hydration and elasticity while offering notable antioxidant benefits.
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