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Moumoujus

CIRSIUM ERIOPHORUM CALLUS EXTRACT.

Valuable / ASTRINGENT

This advanced plant cell culture extract precisely targets key pathways involved in excess sebum production and pore enlargement. It has demonstrated efficacy in normalizing oily skin and refining pores, while simultaneously supporting skin barrier health and stimulating collagen synthesis.

Summary

skin conditioning astringent sebum regulating pore refining anti-inflammatory collagen boosting epidermal barrier support

Science

Mechanism of Action

Cirsium Eriophorum Callus Extract operates at a molecular level to restore skin balance. It modulates 5α-reductase, an enzyme central to sebum secretion, and Kallikrein 5, a trypsin-like serine protease involved in healthy skin exfoliation and antimicrobial response. Furthermore, it actively inhibits the overexpression of proinflammatory cytokines (IL-1α, IL-1β, IL-8, and TNF-α) in keratinocytes and increases collagen production, thereby enhancing epidermal barrier functionality.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–0.5%
Optimal

0.5%

Key findings

  1. 01 A 4-week clinical study demonstrated that a dermo-cosmetic cream containing 0.5% Cirsium Eriophorum Callus Extract, applied twice daily, resulted in significant sebum-normalizing and pore refining activity in individuals with seborrheic or acne-prone skin. This was attributed to the regulation of 5α-reductase and Kallikrein 5, inhibition of pro-inflammatory cytokines (IL-1α, IL-1β, IL-8, TNF-α), and increased collagen synthesis.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5.4 – 5.5
0 7 14

Stability

The extract demonstrates stability within a narrow pH range of 5.4 to 5.5, as observed in a cream formulation. Its water-soluble nature simplifies integration into aqueous cosmetic bases.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific safety assessments by CIR or SCCS have been published, and there is no specific FDA status as a cosmetic ingredient. The EWG Skin Deep database rates it with a low hazard score for various concerns (cancer, allergies, developmental toxicity), though data availability is noted as low. INCIDecoder also suggests low irritancy.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Cirsium Eriophorum Callus Extract is a valuable ingredient for precision skincare, effectively balancing sebum production, refining pores, and providing anti-inflammatory and collagen-boosting benefits, particularly for oily and sensitive skin types.

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