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Moumoujus

CINNAMOMUM OSMOPHLOEUM LEAF EXTRACT.

Insufficient Data / ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Cinnamomum osmophloeum Leaf Extract, derived from the leaves of the indigenous Taiwanese cinnamon tree, is recognized for its multifaceted biological activities. Research indicates its potential in mitigating inflammation, promoting wound healing, and exhibiting antioxidant properties, making it a promising ingredient for targeted skincare applications.

Summary

Anti-inflammatory Antioxidant Wound Healing Tyrosinase Inhibitor Antibacterial

Science

Mechanism of Action

This extract exerts its effects through several pathways, primarily by influencing anti-inflammatory processes via the reduction of proinflammatory cytokines such as IL-1β and IL-6. It demonstrates antioxidant capabilities by neutralizing free radicals and bolstering intrinsic antioxidant defenses. Furthermore, it possesses wound repair capabilities, including the potential to promote dermal cell proliferation, and can inhibit tyrosinase activity, which is relevant for managing hyperpigmentation. Certain constituents, like cinnamaldehyde, also contribute by inhibiting the release of arachidonic acid, a key initiator of inflammatory responses.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In a rat model of 5-Fluororacil-induced oral mucositis, 100 mg/mL of the extract significantly reduced proinflammatory cytokines (IL-1β, IL-6) and advanced wound healing. A 50 mg/mL concentration was not found to be effective, indicating a concentration-dependent effect.
  2. 02 Topical application of 0.8 mg of the extract on rat wounds led to over 30% wound closure by day 3 and more than 50% closure by day 5, showcasing effective wound repair promotion.

Transparency

Dusting Analysis

Not commonly dusted

There is no evidence suggesting Cinnamomum osmophloeum Leaf Extract is commonly 'dusted' at sub-efficacious concentrations. However, due to potential irritation, precision in concentration is critical.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The thermal stability of key essential oil components, such as trans-cinnamaldehyde, can be compromised by high temperatures. Incorporating specific amounts of eugenol may enhance stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

No official safety assessments by CIR, SCCS, or FDA are available for Cinnamomum osmophloeum Leaf Extract. While it contains less coumarin than Cinnamomum cassia, its composition can vary significantly by chemotype. Some extracts may contain high levels of trans-cinnamaldehyde (e.g., 65.03% in hydrosol), which is known to be irritating. Undiluted cinnamon leaf oil is also recognized for causing skin irritation. Careful formulation and concentration control are imperative.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Cinnamomum osmophloeum Leaf Extract presents promising anti-inflammatory, antioxidant, and wound-healing properties in preclinical studies, yet its safety profile and optimal concentrations for human topical application require significantly more rigorous assessment due to the high risk of irritation.

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